Evidence map›Paper›PMID 37559983›Full record

ArticleAmerican journal of cancer research2023

Anti-tumor effects of deubiquitinating enzyme inhibitor PR-619 in human chondrosarcoma through reduced cell proliferation and endoplasmic reticulum stress-related apoptosis.

Wei-Chou Lin, Yen-Lin Chiu, Kuan-Lin Kuo, Po-Ming Chow, Chen-Hsun Hsu, Shih-Ming Liao, Jun-Ren Dong, Shih-Chen Chang, Shing-Hwa Liu, Tsai-Jung Liu and 5 more

Abstract read
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Article in American journal of cancer research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wei-Chou LinDepartment of Pathology, National Taiwan University Hospital, College of Medicine, National Taiwan University Taipei, Taiwan.
Yen-Lin ChiuDepartment of Medical Research, Far Eastern Memorial Hospital New Taipei, Taiwan.
Kuan-Lin KuoGraduate Institute of Toxicology, College of Medicine, National Taiwan University Taipei, Taiwan.
Po-Ming ChowGraduate Institute of Toxicology, College of Medicine, National Taiwan University Taipei, Taiwan.
Chen-Hsun HsuDepartment of Pathology, National Taiwan University Hospital, College of Medicine, National Taiwan University Taipei, Taiwan.
Shih-Ming LiaoDepartment of Pathology, National Taiwan University Hospital, College of Medicine, National Taiwan University Taipei, Taiwan.
Jun-Ren DongDepartment of Urology, College of Medicine, National Taiwan University Taipei, Taiwan.
Shih-Chen ChangDepartment of Surgery, Taipei Veterans General Hospital Taipei, Taiwan.
Shing-Hwa LiuGraduate Institute of Toxicology, College of Medicine, National Taiwan University Taipei, Taiwan.
Tsai-Jung LiuDepartment of Pathology, National Taiwan University Hospital, College of Medicine, National Taiwan University Taipei, Taiwan.
Fu-Shun HsuDepartment of Surgery, Yangming Branch of Taipei City Hospital Taipei, Taiwan.
Kuo-Chuan WangDepartment of Surgery, National Taiwan University Hospital Taipei, Taiwan.
Yi-Chih LinDepartment of Otolaryngology, Shuang Ho Hospital, Taipei Medical University New Taipei, Taiwan.
Chen-Chih ChangDepartment of Pathology, National Taiwan University Hospital, College of Medicine, National Taiwan University Taipei, Taiwan.
Kuo-Yuan HuangDepartment of Orthopedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chondrosarcoma, a treatment-resistant cancer with limited therapeutic options, lacks significant advancements in treatment methods. However, PR-619, a novel inhibitor of deubiquitinating enzymes, has demonstrated anti-tumor effects in various malignancies. This study aimed to investigate the impact of PR-619 on chondrosarcoma both

Indexed as

apoptosischondrosarcomaDeubiquitinating enzymeendoplasmic reticulum stress

Identifiers

PMID37559983
PMCPMC10408468

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.