Evidence map›Paper›PMID 37559908›Full record

ArticleiScience2023

Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development.

Ilaria Guccini, Guanghui Tang, Trang Thuy To, Laura Di Rito, Solange Le Blanc, Oliver Strobel, Mariantonietta D'Ambrosio, Emiliano Pasquini, Marco Bolis, Pamuditha Silva and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ilaria GucciniInstitute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.
Guanghui TangInstitute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.
Trang Thuy ToInstitute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.
Laura Di RitoComputational Oncology Unit, Department of Oncology, Istituto di Richerche Farmacologiche 'Mario Negri' IRCCS, 20156 Milano, Italy.
Solange Le BlancEuropean Pancreas Center, Department of General Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Oliver StrobelEuropean Pancreas Center, Department of General Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Mariantonietta D'AmbrosioInstitute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), 6500 Bellinzona, Switzerland.
Emiliano PasquiniInstitute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), 6500 Bellinzona, Switzerland.
Marco BolisInstitute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), 6500 Bellinzona, Switzerland.
Pamuditha SilvaInstitute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.
Hasan Ali KabakciInstitute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.
Svenja GodbersenInstitute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.
Andrea AlimontiInstitute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), 6500 Bellinzona, Switzerland.
Gerald SchwankInstitute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.
Markus StoffelInstitute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although dietary fructose is associated with an elevated risk for pancreatic cancer, the underlying mechanisms remain elusive. Here, we report that ketohexokinase (KHK), the rate-limiting enzyme of fructose metabolism, is a driver of PDAC development. We demonstrate that fructose triggers KHK and induces fructolytic gene expression in mouse and human PDAC. Genetic inactivation of

Indexed as

BiochemistryBiological sciencesCancer systems biologyNatural sciencesSystems biology

Identifiers

PMID37559908
PMCPMC10407955

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.