Evidence map›Paper›PMID 37559725›Full record

ArticleFrontiers in immunology2023

T cell intrinsic STAT1 signaling prevents aberrant Th1 responses during acute toxoplasmosis.

Aaron B Schultz, David G Kugler, Luis Nivelo, Nicolas Vitari, Laura P Doyle, Svetlana Ristin, Lothar Hennighausen, John J O'Shea, Dragana Jankovic, Alejandro V Villarino

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Aaron B SchultzDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, United States.
David G KuglerImmunoparasitology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Luis NiveloDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, United States.
Nicolas VitariDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, United States.
Laura P DoyleSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, United States.
Svetlana RistinDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, United States.
Lothar HennighausenNational Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
John J O'SheaLymphocyte Cell Biology Section, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, United States.
Dragana JankovicImmunoparasitology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Alejandro V VillarinoDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, United States.
University of Miami · USNational Institutes of Health · USSylvester Comprehensive Cancer Center · USNational Institute of Allergy and Infectious Diseases · USNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Stat transcription factors in immunoregulation and autoimmune diseaseZIAAR041159 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI O'SHEA, JOHN · 2009 to 2025
$49.3M
Genetic Approaches To Understanding Organ Development and FunctionZIADK061000 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HENNIGHAUSEN, LOTHAR · 2009 to 2025
$24.7M
Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI George S. Grills · 2019 to 2026
$24.1M
Predoctoral Training in Translational ImmunologyT32AI162624 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Thomas R Malek · 2022 to 2026
$894k
NCI NIH HHS P30 CA240139NIAID NIH HHS T32 AI162624
6 · The paper itself

Abstract

Infection-induced T cell responses must be properly tempered and terminated to prevent immuno-pathology. Using transgenic mice, we demonstrate that T cell intrinsic STAT1 signaling is required to curb inflammation during acute infection with

Indexed as

cytokineIL-10 (interleukin 10)IL-13 (interleukin 13)IL-27 (interleukin 27)JAK - STAT signaling pathwaySTAT1STAT3toxoplasama gondii

Identifiers

PMID37559725
PMCPMC10407301
OpenAlexW4385240362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.