Evidence map›Paper›PMID 37559696›Full record

ArticleNewborn (Clarksville, Md.)2023

Neurological Manifestations of Perinatal Dengue.

Srijan Singh, Jubara Alallah, Astha Amrit, Akhil Maheshwari, Suresh Boppana

Open access · bronzeAbstract read
In one paragraph

Article in Newborn (Clarksville, Md.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Srijan SinghDepartment of Pediatrics, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra, India.
Jubara AlallahDepartment of Pediatrics, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Saudi Arabia.
Astha AmritDepartment of Neonatology, Bai Jerbai Wadia Hospital for Children, Mumbai, Maharashtra, India.
Akhil MaheshwariDepartment of Pediatrics, Division of Neonatal Medicine, Louisiana State University - Shreveport, Shreveport, Louisiana; Global Newborn Society, Baltimore, Maryland, United States of America.
Suresh BoppanaDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Bai Jerbai Wadia Hospital for Children · INGovernment Medical College · INKing Abdulaziz Medical City · SALouisiana State University in Shreveport · USUniversity of Alabama at Birmingham · US

Funding

Congenital CMV and CNS Infection Mechanisms of Protective ImmunityR01AI089956 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI William Jarvis Britt · 2011 to 2026
$7.7M
Project-002U01CA260462 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOPPANA, SURESH B, BRITT, WILLIAM JARVIS · 2020 to 2023
$4.0M
Acquisition of HCMV from breast milk-correlates of protectionR01AI109001 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOPPANA, SURESH B · 2014 to 2017
$2.8M
NCI NIH HHS U01 CA260462NIAID NIH HHS R01 AI089956NIAID NIH HHS R01 AI109001
6 · The paper itself

Abstract

Dengue viruses (DENVs) are single-stranded RNA viruses belonging to the family Flaviviridae. There are four distinct antigenically related serotypes, DENVs types 1, 2, 3, and 4. These are all mosquito-borne human pathogens. Congenital dengue disease occurs when there is mother-to-fetus transmission of the virus and should be suspected in endemic regions in neonates presenting with fever, maculopapular rash, and thrombocytopenia. Although most of the infected infants remain asymptomatic, some can develop clinical manifestations such as sepsis-like illness, gastric bleeding, circulatory failure, and death. Neurological manifestations include intracerebral hemorrhages, neurological malformations, and acute focal/disseminated encephalitis/encephalomyelitis. Dengue NS1Ag, a highly conserved glycoprotein, can help the detection of cases in the viremic stage. We do not have proven specific therapies yet; management is largely supportive and is focused on close monitoring and maintaining adequate intravascular volume.

Indexed as

Antibody-dependent enhancementCongenital dengueCYD-TDV (Dengvaxia)Dengue encephalitisIgM:IgG ratioNeonateNeurotropismNS1AgTAK-003Vertical transmission

Identifiers

PMID37559696
PMCPMC10411360
OpenAlexW4383551518

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.