Evidence map›Paper›PMID 37559390›Full record

ArticlePharmaceutical biology2023

Liver protective effect of chloroform extract of

Zainul Amiruddin Zakaria, Adibah Sahmat, Azfar Hizami Azmi, Amal Syahirah Nur Zainol, Maizatul Hasyima Omar, Tavamani Balan, Arifah Abdul Kadir, Syahriel Abdullah, Roro Azizah, Lilis Sulistyorini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Zainul Amiruddin ZakariaBorneo Research on Algesia, Inflammation and Neurodegeneration (BRAIN) Group, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Jalan UMS, Sabah, Malaysia.
Adibah SahmatDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
Azfar Hizami AzmiDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
Amal Syahirah Nur ZainolDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
Maizatul Hasyima OmarHerbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Shah Alam, Malaysia.
Tavamani BalanFaculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Perak, Malaysia.
Arifah Abdul KadirDepartment of Veterinary Pre-clinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor, Malaysia.
Syahriel AbdullahInstitute of Tropical Biology and Conservation, Universiti Malaysia Sabah, Jalan UMS, Sabah, Malaysia.
Roro AzizahDepartment of Environmental Health, Faculty of Public Health, Campus C Universitas Airlangga, Jalan Mulyorejo Surabaya, East Java, Indonesia.
Lilis SulistyoriniDepartment of Environmental Health, Faculty of Public Health, Campus C Universitas Airlangga, Jalan Mulyorejo Surabaya, East Java, Indonesia.
Universiti Putra Malaysia · MYAirlangga University · IDUniversiti of Malaysia Sabah · MYInstitute for Medical Research · MYUniversity of Kuala Lumpur · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

context

objectiveThis study elucidates the hepatoprotective activity of chloroform extract of MATERIALS AND

methodsMale Sprague-Dawley rats (

resultsCEBP significantly ( DISCUSSION AND

conclusionsCEBP exerts its hepatoprotective activity through a non-free radical scavenging pathway that involves activation of the endogenous enzymatic antioxidant defense system. Further study is needed to identify the responsible bioactive compounds before the plant can be developed as a future alternative hepatoprotective medicament for clinical use.

Indexed as

BauhiniaChemical and Drug Induced Liver InjuryAcetaminophenAnimalsAntioxidantsChloroformFlavonoidsLiverPlant ExtractsPlant LeavesRatsRats, Sprague-DawleyAcetaminophenAntioxidantsChloroformFlavonoidsPlant Extractsendogenous antioxidant enzymes systemhepatoprotectionLiver injurynon-free radical scavengingparacetamol intoxication

Identifiers

PMID37559390
PMCPMC10416740
OpenAlexW4385716618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.