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ArticleJournal of clinical research in pediatric endocrinology2025

A 15-year-old Girl with a Lateral Neck Mass Turning Out to Be Papillary Thyroid Carcinoma - Lateral Ectopic Papillary Thyroid Carcinoma or Lymph Node Metastasis?

Marijke E B Kremer, A S Paul van Trotsenburg, Anton F Engelsman, Esther Edelenbos, Arantza Farina-Sarasqueta, Joost van Schuppen, José C C Koppes, Joep P M Derikx, Christiaan F Mooij

Abstract readCase Reports
In one paragraph

Article in Journal of clinical research in pediatric endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marijke E B KremerDepartment of Pediatric Surgery, Emma Children’s Hospital, Amsterdam University Medical Centers, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The NetherlandsORCID 0000-0002-6032-0562
A S Paul van TrotsenburgDepartment of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The NetherlandsORCID 0000-0002-9677-7441
Anton F EngelsmanDepartment of Surgery, Amsterdam University Medical Centers, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The NetherlandsORCID 0000-0003-4943-8882
Esther EdelenbosDepartment of Pediatric Oncology, Emma Children’s Hospital, Amsterdam University Medical Centers, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The NetherlandsORCID 0000-0002-9226-856X
Arantza Farina-SarasquetaDepartment of Pathology, Amsterdam University Medical Centers, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The NetherlandsORCID 0000-0002-4307-1568
Joost van SchuppenDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The NetherlandsORCID 0000-0003-4982-6615
José C C KoppesDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The NetherlandsORCID 0009-0001-3527-6221
Joep P M DerikxDepartment of Pediatric Surgery, Emma Children’s Hospital, Amsterdam University Medical Centers, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The NetherlandsORCID 0000-0003-0694-7679
Christiaan F MooijDepartment of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The NetherlandsORCID 0000-0001-7977-6271

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lateral neck lesions in children are common and involve various infectious or inflammatory etiologies, as well as embryological remnants such as branchial cleft cysts. Although unusual, ectopic thyroid tissue may also present as a lateral neck mass. Here, we present an unusual case of a 15-year-old girl treated for an asymptomatic lateral neck mass that, after surgical removal, was found to be papillary thyroid carcinoma (PTC). However, after removal of the thyroid gland, no primary thyroid tumor was found. The question arose whether genethe lateral neck lesion was a lymph node metastasis without identifiable primary tumor by histological evaluation, or rather malignant degeneration of ectopic thyroid tissue. Total thyroidectomy was performed with postoperative adjuvant radioactive iodine ablation. Even though PTC in a lateral neck mass without a primary thyroid tumor has been described previously, pediatric cases have not been reported. In this report we share our experience on diagnosis, treatment and follow-up, and review the existing literature.

Indexed as

Carcinoma, PapillaryThyroid NeoplasmsAdolescentFemaleHumansLymphatic MetastasisNeckThyroid Cancer, PapillaryThyroidectomycervical neck massThyroid dysgenesisthyroid papillary carcinoma

Identifiers

PMID37559363
PMCPMC12118322

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.