ArticleBMC surgery2023
Association between anion gap and all-cause mortality of critically ill surgical patients: a retrospective cohort study.
Article in BMC surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Dynamics of serum anion gaps with in-hospital mortality: Analysis of the multi-open databases.PloS one · 2024Pooled it
- Association between enteral nutrition timing and postoperative anion gap trajectory in cardiac surgery ICU patients: a retrospective study based on the MIMIC-IV database.Journal of cardiothoracic surgery · 2026Article
- Prediction hospital mortality for critical illness lung cancer patients with pneumonia.BMC infectious diseases · 2026Article
- Association Between Serum Anion Gap and Risk of Postoperative Delirium in Patients Undergoing Gastric Surgery in ICU: A Retrospective Study From the MIMIC-IV Database.Anesthesiology research and practice · 2026Article
- How Long Do We Have? A Retrospective Review of Palliative Extubation in the Burn Unit.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Relationship between time-weighted average anion gap and mortality in septic shock patients: a retrospective analysis of the MIMIC-IV database.BMC infectious diseases · 2025Article
- Albumin-corrected anion gap predicts acute kidney injury in critically ill patients with acute pancreatitis: a retrospective cohort study.BMC nephrology · 2025Article
- Anion gap associated with 28-days all-cause mortality in Acute cholangitis patients admitted to the intensive care unit in MIMIC-IV database: a retrospective cohort study.Frontiers in medicine · 2025Article
- Prediction of the need for surgery in patients with unruptured abdominal aortic aneurysm based on SOFA score.PloS one · 2025Article
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- Prognostic value of the systemic immune-inflammation index in critically ill elderly patients with hip fracture: evidence from MIMIC (2008-2019).Frontiers in medicine · 2024Article
- Albumin corrected anion gap for predicting in-hospital death among patients with acute myocardial infarction: A retrospective cohort study.Clinics (Sao Paulo, Brazil) · 2024Article
- A nomogram to predict 28-day mortality in patients with sepsis combined coronary artery disease: retrospective study based on the MIMIC-III database.Frontiers in medicine · 2024Article
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4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThere are few widely accepted and operationally feasible models for predicting the mortality risk of patients in surgical intensive care unit (SICU). Although serum anion gap (AG) is known to be correlated with severe metabolic acidosis, no investigations have been reported about the association between AG level and the outcome during hospitalization in SICU. This study aimed to explore the predictive power of AG for 90-day all-cause mortality in SICU.
methodsData of the eligible patients in SICU from 2008 to 2019 was obtained from the Medical Information Mart for Intensive Care IV version 2.0 (MIMIC-IV v2.0) database. Baseline clinical data of the selected patients was compared in different groups stratified by the outcome during their admission via univariate analysis. Restricted cubic spline (RCS) was drawn to confirm the relationship of AG and the short-term mortality. Kaplan-Meier survival curve was plotted in different AG level groups. Univariate and multivariate Cox analyses were performed, and Cox proportional-hazards models were built to investigate an independent role of AG to predict 90-day all-cause mortality risk in SICU. Receiver operating characteristics (ROC) curves analysis was performed to evaluate the predictive value of AG on the 90-day prognosis of patients.
resultsA total of 6,395 patients were enrolled in this study and the 90-day all-cause mortality rate was 18.17%. Univariate analysis showed that elevated serum AG was associated with higher mortality (P < 0.001). RCS analysis indicated a positively linear relationship between serum AG and the risk of 90-day all-cause mortality in SICU (χ
conclusionsElevated AG (≥ 14.10 mmol/L) is an independent risk factor for predicting severe conditions and poor prognosis of critical ill surgical patients.
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