Evidence map›Paper›PMID 37558924›Full record

ArticleScientific reports2023

Race-specific association of an IRGM risk allele with cytokine expression in human subjects.

Teminioluwa Ajayi, Prashant Rai, Min Shi, Kristin A Gabor, Peer W F Karmaus, Julie M Meacham, Kevin Katen, Jennifer H Madenspacher, Shepherd H Schurman, Michael B Fessler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Teminioluwa AjayiImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, MD D2-01, P.O. Box 12233, Research Triangle Park, NC, 27709, USA.
Prashant RaiImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, MD D2-01, P.O. Box 12233, Research Triangle Park, NC, 27709, USA.
Min ShiBiostatistics & Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Kristin A GaborImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, MD D2-01, P.O. Box 12233, Research Triangle Park, NC, 27709, USA.
Peer W F KarmausImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, MD D2-01, P.O. Box 12233, Research Triangle Park, NC, 27709, USA.
Julie M MeachamImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, MD D2-01, P.O. Box 12233, Research Triangle Park, NC, 27709, USA.
Kevin KatenSignal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Jennifer H MadenspacherImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, MD D2-01, P.O. Box 12233, Research Triangle Park, NC, 27709, USA.
Shepherd H SchurmanClinical Research Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Michael B FesslerImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, MD D2-01, P.O. Box 12233, Research Triangle Park, NC, 27709, USA. fesslerm@niehs.nih.gov.
National Institute of Environmental Health Sciences · USTriangle · US

Funding

Molecular Genetics Support to Identify Gene/Environment Interactions in DiseaseZICES102546 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI GERRISH, KEVIN · 2009 to 2025
$30.5M
Cell Signaling of Host DefenseZ01ES102005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FESSLER, MICHAEL B · 2006 to 2008
$3.3M
Intramural NIH HHS Z01 ES102005NIEHS NIH HHS Z01 ES102005
6 · The paper itself

Abstract

Immunity-related GTPase family M (IRGM), located on human chromosome 5q33.1, encodes a protein that promotes autophagy and suppresses the innate immune response. The minor allele of rs13361189 (-4299T>C), a single nucleotide polymorphism in the IRGM promoter, has been associated with several diseases, including Crohn's disease and tuberculosis. Although patterns of linkage disequilibrium and minor allele frequency for this polymorphism differ dramatically between subjects of European and African descent, studies of rs13361189 have predominantly been conducted in Europeans and the mechanism of association is poorly understood. We recruited a cohort of 68 individuals (30 White, 34 African American, 4 other race) with varying rs13361189 genotypes and assessed a panel of immune response measures including whole blood cytokine induction following ex vivo stimulation with Toll-like Receptor ligands. Minor allele carriers were found to have increased serum immunoglobulin M, C-reactive protein, and circulating CD8

Indexed as

CytokinesGenetic Predisposition to DiseaseAllelesCase-Control StudiesCD8-Positive T-LymphocytesGTP-Binding ProteinsHumansPolymorphism, Single NucleotideCytokinesGTP-Binding ProteinsIRGM protein, human

Identifiers

PMID37558924
PMCPMC10412543
OpenAlexW4385693070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.