ArticleNature2023
Mitochondrial integrated stress response controls lung epithelial cell fate.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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100citing papers in PubMed
35.4field-weighted citation impact, top 1% of its field
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Who cites it
100 citing papers in PubMed, 138 citations in OpenAlex.
- A macrophage-mimetic nanocarrier co-loaded with geraniol and FK13-a1 for MRSA-induced acute lung injury.Drug delivery · 2026Article
- Fuelling repair: metabolic regulation of alveolar type 2 cell fate in lung regeneration and disease.Disease models & mechanisms · 2026Review
- Nicotinamide Mononucleotide Combined Glucose Counteracts Iron Overload-Induced Mitochondrial Dysfunction in Mice Under Hypobaric Hypoxia.Molecular & cellular proteomics : MCP · 2026Article
- Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung Fibrosis.bioRxiv : the preprint server for biology · 2026Article
- Adenine nucleotide translocase 2 (ANT2) deficiency reprograms ferroptosis in alveolar progenitor cells to promote emphysema.bioRxiv : the preprint server for biology · 2026Article
- Integrated stress response couples mitochondrial fitness with lineage reprogramming to drive cancer evolution.Nature cell biology · 2026Article
- Targeting Post-Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual-Action Approach for Antioxidant and Immune Modulation.Advanced healthcare materials · 2026Article
- Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease.Physiological reviews · 2026Review
- Inhibition of the mitochondrial pyruvate carrier attenuates the integrated stress response activation in a cellular model of Huntington's disease.Molecular and cellular biochemistry · 2026Article
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- Oxidative stress-induced endothelial dysfunction drives mechanical and infectious lung injury: Therapeutic potential of kaempferol in males.Redox biology · 2026Article
- Multiple mechanisms lead to loss-of-function effects of pathogenic SARS2 variants.Disease models & mechanisms · 2026Article
- Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell renewal in idiopathic pulmonary fibrosis.The Journal of clinical investigation · 2026Article
- AMC-F1 regulates mitochondria-autophagy crosstalk independent of nutrient stress.Nature communications · 2026Article
- Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026Review
- Ketone body metabolism activates the immune response againstCell insight · 2026Article
- Cardiolipin preserves TNature metabolism · 2026Article
- Mitochondrial protein import stress causes lysosomal damage and progressive tissue atrophy.EMBO reports · 2026Article
- Progenitor Resilience and the Early Onset of Chronic Lung Diseases: NHLBI workshop report.American journal of respiratory cell and molecular biology · 2026Article
- Metabolic and transcriptional plasticity supports CD8Immunity · 2026Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 4 countries.
SeungHye HanDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA. shan@northwestern.edu.ORCID 0000-0001-5625-6337
Minho LeeDepartment of Life Science, Dongguk University-Seoul, Goyang-si, Republic of Korea.ORCID 0000-0002-0168-9546
Youngjin ShinDepartment of Life Science, Dongguk University-Seoul, Goyang-si, Republic of Korea.ORCID 0000-0003-1373-7557
Regina GiovanniDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA.
Ram P ChakrabartyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-5425-6306
Mariana M HerreriasDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA.
Laura A DadaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-0474-718X
Annette S FlozakDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA.
Paul A ReyfmanDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA.
Basil KhuderDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA.
Colleen R ReczekDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA.
Lin GaoInstituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, Seville, Spain.ORCID 0000-0002-1781-4671
José Lopéz-BarneoInstituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, Seville, Spain.
Cara J GottardiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-0912-7617
G R Scott BudingerDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-3114-5208
Navdeep S ChandelDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA. nav@northwestern.edu.ORCID 0000-0001-7208-3886
Northwestern University · USDongguk University · KRInstituto de Biomedicina de Sevilla · ES
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MRole of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2003 to 2019
$30.8MTissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Alexander Misharin · 2015 to 2026
$26.9MThe Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2021 to 2026
$18.9MTraining Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6MMitochondrial metabolism and ROS regulate cancerR35CA197532 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANDEL, NAVDEEP S · 2016 to 2022
$6.3MWnt-beta-catenin cross interactions in alveolar macrophages and epithelial cells in persistence of SSc-ILDR01HL134800 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOTTARDI, CARA J · 2018 to 2021
$2.9MAlveolar epithelial stress-induced polyploidization in lung injury and repairR01HL163611 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOTTARDI, CARA J · 2022 to 2025
$2.5MMitochondrial metabolic regulation of lung epithelium: alveolar generation and regenerationK08HL143138 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HAN, SEUNGHYE · 2019 to 2023
$816kSingle-Cell Transcriptomic Analysis to Identify Drivers of Pulmonary FibrosisK08HL146943 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI REYFMAN, PAUL A · 2020 to 2021
$326kMitochondrial metabolism as a therapeutic target in pulmonary fibrosisI01CX001777 · VA · JESSE BROWN VA MEDICAL CENTER · PI GR Scott Budinger, MANU JAIN · 2019 to 2026
–CSRD VA I01 CX001777NCI NIH HHS P30 CA060553NCI NIH HHS R35 CA197532NHLBI NIH HHS K08 HL143138NHLBI NIH HHS K08 HL146943NHLBI NIH HHS P01 HL071643NHLBI NIH HHS P01 HL154998NHLBI NIH HHS R01 HL134800NHLBI NIH HHS R01 HL163611NHLBI NIH HHS T32 HL076139NIA NIH HHS P01 AG049665
Abstract
Alveolar epithelial type 1 (AT1) cells are necessary to transfer oxygen and carbon dioxide between the blood and air. Alveolar epithelial type 2 (AT2) cells serve as a partially committed stem cell population, producing AT1 cells during postnatal alveolar development and repair after influenza A and SARS-CoV-2 pneumonia
Indexed as
Alveolar Epithelial CellsCell DifferentiationCell LineageLungMitochondriaStress, PhysiologicalAnimalsElectron Transport Complex IMiceNADNADH DehydrogenaseProtonsRNA-SeqSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSingle-Cell Gene Expression AnalysisElectron Transport Complex INADNADH DehydrogenaseNdi1 protein, S cerevisiaeNdufs2 protein, mouseProtonsSaccharomyces cerevisiae ProteinsSDHD protein, mouseSuccinate Dehydrogenase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.