ArticleNature2023
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells.
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In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 1 pooled it
24.8field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
121 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
- Probiotics and the Potential of Genetic Modification as a Possible Treatment for Food Allergy.Nutrients · 2023Pooled it
- Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation.Gut microbes · 2026Article
- Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host.Gut microbes · 2026Review
- Nutritional regulation of gut-brain immune crosstalk across the lifespan.Gut microbes · 2026Review
- Engineered bacteria in disease diagnosis and therapy: A synthetic biology perspective.Synthetic and systems biotechnology · 2026Review
- Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation.Signal transduction and targeted therapy · 2026Review
- Dynamic metabolic programming of monocyte-derived cells defines immunity in CNS disease.Brain : a journal of neurology · 2026Review
- XBP1 signaling from tumor metabolic stress to myeloid driven immunotherapy resistance (Review).International journal of molecular medicine · 2026Review
- Neuroimmune interactions: from molecular mechanisms to therapeutic targets.Molecular biomedicine · 2026Review
- Dendritic Cell Dysfunction Underlies Immune Escape After Adoptive Cellular Therapy in Glioblastoma.Cancers · 2026Article
- A Lactate-H4K12la-HDAC1 epigenetic axis governs microglial state transitions during experimental autoimmune encephalomyelitis in female mice.Nature communications · 2026Article
- Understanding the epigenetic regulation of lactylation and aberrant lactate metabolism in cancer: From mechanisms to therapeutic strategies (Review).International journal of oncology · 2026Review
- BRG1-mediated suppression of ferroptosis underlies BTK inhibitor resistance.Nature communications · 2026Article
- Functional Integration of Crosstalk Between Probiotic Lactic Acid Bacteria and Intestinal Immunity Signaling.Probiotics and antimicrobial proteins · 2026Review
- Lactate Accelerates Early Angiogenesis and Bone Regeneration Through Macrophage M1 Polarisation.Cell proliferation · 2026Article
- Lactate-Mediated Brain Acidosis Drives Epigenetic Dysregulation of TGFB2 and Associated Gene Networks in Schizophrenia and Bipolar Disorder.International journal of molecular sciences · 2026Article
- Glial cells in chronic inflammation: diversity, dysfunction and therapeutic targeting.Nature reviews. Immunology · 2026Review
- Mesoporous polydopamine nanoplatform enhances IL-2 immunotherapy for hepatocellular carcinoma via mild photothermal therapy and lactate regulation.Asian journal of pharmaceutical sciences · 2026Article
- Lactate metabolism and lactylation in cancer: from pathogenesis to therapeutic advances.Signal transduction and targeted therapy · 2026Review
- Elevated lactate production exacerbates PM2.5-induced pulmonary fibrosis by stabilizing TGF-β1.Journal of advanced research · 2026Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
35 authors at 4 institutions in 2 countries.
Liliana M SanmarcoAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Joseph M RoneAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0009-0001-9130-0249
Carolina M PolonioAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-0460-0161
Gonzalo Fernandez LahoreAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Federico GiovannoniAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Kylynne FerraraAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Cristina Gutierrez-VazquezAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-3846-4631
Ning LiSynlogic Therapeutics, Cambridge, MA, USA.
Anna SokolovskaSynlogic Therapeutics, Cambridge, MA, USA.ORCID 0000-0002-1216-696X
Agustin PlasenciaAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-7415-0947
Camilo Faust AklAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Payal NandaAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Evelin S HeckAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Zhaorong LiAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-5268-6986
Hong-Gyun LeeAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0001-5960-5504
Chun-Cheih ChaoAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-4108-2658
Claudia M Rejano-GordilloAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-4586-5975
Pedro H Fonseca-CastroAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Tomer IllouzAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-4123-6469
Mathias LinnerbauerAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-5528-5141
Jessica E KenisonAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Rocky M BarillaAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Daniel FarrenkopfAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Nikolas A StevensAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Gavin PiesterAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0001-8413-7298
Elizabeth N ChungAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Lucas DaileyBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-3204-9565
Vijay K KuchrooAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0001-7177-2110
David HavaSynlogic Therapeutics, Cambridge, MA, USA.ORCID 0000-0002-9200-1566
Michael A WheelerAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-0689-6384
Clary ClishBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-8259-9245
Roni NowarskiAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Eduardo BalsaCentro de Biología Molecular Severo Ochoa UAM-CSIC, Universidad Autónoma de Madrid, Madrid, Spain.
Jose M LoraSynlogic Therapeutics, Cambridge, MA, USA.
Francisco J QuintanaAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA. fquintana@rics.bwh.harvard.edu.ORCID 0000-0001-8156-0736
Brigham and Women's Hospital · USBroad Institute · USSynlogic (United States) · USCentro de Biología Molecular Severo Ochoa · ES
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6MAHR-mediated immunosuppression in glioblastomaR01ES029136 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI Francisco J. Quintana, DAVID A REARDON · 2019 to 2026
$3.3MControl of extracellular matrix remodeling by CD29+ astrocytesR01MH130458 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael Alex Wheeler · 2022 to 2026
$2.1MRegulation of CNS AutoimmunityR01AI126880 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI QUINTANA, FRANCISCO J. · 2017 to 2021
$2.1MControl of Local CNS InflammationR01NS102807 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI QUINTANA, FRANCISCO J. · 2018 to 2022
$1.8MPathogenic Astrocyte Populations in EAE and MSR01NS129778 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Francisco J. Quintana · 2023 to 2026
$1.7MMolecular Control of Astrocytes in CNS InflammationR00NS114111 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI WHEELER, MICHAEL ALEX · 2023 to 2025
$783kMolecular Control of Astrocytes in CNS InflammationK99NS114111 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI WHEELER, MICHAEL ALEX · 2020 to 2021
$189kThe role of the IFNAR1/AhR signaling axis in astrocyte regulation and remediation of multiple sclerosis pathogenesisF32NS101790 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI WHEELER, MICHAEL ALEX · 2017 to 2019
$117kNIAID NIH HHS R01 AI126880NIDDK NIH HHS P30 DK040561NIEHS NIH HHS R01 ES029136NIMH NIH HHS R01 MH130458NINDS NIH HHS F32 NS101790NINDS NIH HHS K99 NS114111NINDS NIH HHS R00 NS114111NINDS NIH HHS R01 NS102807NINDS NIH HHS R01 NS129778
Abstract
Dendritic cells (DCs) have a role in the development and activation of self-reactive pathogenic T cells
Indexed as
Autoimmune DiseasesCentral Nervous SystemDendritic CellsHypoxia-Inducible Factor 1, alpha SubunitLactic AcidAutoimmunityElectron Transport Complex IFeedback, PhysiologicalHumansLactaseProbioticsReactive Oxygen SpeciesSingle-Cell AnalysisT-LymphocytesX-Box Binding Protein 1Electron Transport Complex IHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitLactaseLactic AcidNDUFA4L2 protein, humanReactive Oxygen SpeciesX-Box Binding Protein 1XBP1 protein, human
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.