Evidence map›Paper›PMID 37558677›Full record

ArticleNature communications2023

Dynamics of cortical contrast adaptation predict perception of signals in noise.

Christopher F Angeloni, Wiktor Młynarski, Eugenio Piasini, Aaron M Williams, Katherine C Wood, Linda Garami, Ann M Hermundstad, Maria N Geffen

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Cortical Zinc Signaling Is Necessary for Changes in Mouse Pupil Diameter That Are Evoked by Background Sounds with Different Contrasts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christopher F AngeloniPsychology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA.
Wiktor MłynarskiFaculty of Biology, Ludwig Maximilian University of Munich, Munich, Germany.
Eugenio PiasiniInternational School for Advanced Studies (SISSA), Trieste, Italy.ORCID http://orcid.org/0000-0003-0384-7699
Aaron M WilliamsDepartment of Otorhinolaryngology, University of Pennsylvania, Philadelphia, PA, USA.
Katherine C WoodDepartment of Otorhinolaryngology, University of Pennsylvania, Philadelphia, PA, USA.
Linda GaramiDepartment of Otorhinolaryngology, University of Pennsylvania, Philadelphia, PA, USA.
Ann M HermundstadJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0000-0002-0377-0516
Maria N GeffenDepartment of Otorhinolaryngology, University of Pennsylvania, Philadelphia, PA, USA. mgeffen@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-3022-2993

Funding

Circuit Mechanisms of Sound Processing and Detection in the Auditory PathwayR01DC014479 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI GEFFEN, MARIA NEIMARK · 2015 to 2024
$4.7M
Neuronal circuits supporting learning-driven changes in auditory perception.R01DC015527 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI Maria Neimark Geffen · 2017 to 2026
$4.5M
Neuronal circuits for context-driven bias in auditory categorizationR01NS113241 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI COHEN, YALE E, GEFFEN, MARIA NEIMARK · 2019 to 2023
$3.5M
Cross-disciplinary training in computational approaches to the neuroscience of audition and communicationT32DC016903 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI Vijay Balasubramanian, Yale E Cohen · 2018 to 2026
$1.4M
The function of cortical gain adaptation in detecting sounds in noise.F31DC016524 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI ANGELONI, CHRISTOPHER F. · 2017 to 2019
$123k
NIDCD NIH HHS F31 DC016524NIDCD NIH HHS R01 DC014479NIDCD NIH HHS R01 DC015527NIDCD NIH HHS T32 DC016903NINDS NIH HHS R01 NS113241
6 · The paper itself

Abstract

Neurons throughout the sensory pathway adapt their responses depending on the statistical structure of the sensory environment. Contrast gain control is a form of adaptation in the auditory cortex, but it is unclear whether the dynamics of gain control reflect efficient adaptation, and whether they shape behavioral perception. Here, we trained mice to detect a target presented in background noise shortly after a change in the contrast of the background. The observed changes in cortical gain and behavioral detection followed the dynamics of a normative model of efficient contrast gain control; specifically, target detection and sensitivity improved slowly in low contrast, but degraded rapidly in high contrast. Auditory cortex was required for this task, and cortical responses were not only similarly affected by contrast but predicted variability in behavioral performance. Combined, our results demonstrate that dynamic gain adaptation supports efficient coding in auditory cortex and predicts the perception of sounds in noise.

Indexed as

Auditory CortexAuditory PerceptionAcoustic StimulationAdaptation, PhysiologicalAnimalsMiceNoiseSound

Identifiers

PMID37558677
PMCPMC10412650

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.