Evidence map›Paper›PMID 37558484›Full record

ArticleInternal medicine (Tokyo, Japan)2024

Clinical Impact of the Charlson Comorbidity Index on the Efficacy of Salvage Photodynamic Therapy Using Talaporfin Sodium for Esophageal Cancer.

Kengo Kai, Koji Nakashima, Hiroshi Kawakami, Shinsuke Takeno, Yoshitaka Hishikawa, Makoto Ikenoue, Takeomi Hamada, Naoya Imamura, Tomotaka Shibata, Tomoaki Noritomi and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Kengo KaiDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Japan.
Koji NakashimaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Japan.
Hiroshi KawakamiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Japan.
Shinsuke TakenoDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Japan.
Yoshitaka HishikawaDepartment of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki, Japan.
Makoto IkenoueDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Japan.
Takeomi HamadaDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Japan.
Naoya ImamuraDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Japan.
Tomotaka ShibataDepartment of Gastroenterological and Pediatric Surgery, Oita University, Japan.
Tomoaki NoritomiDepartment of Surgery, Fukuoka Tokushukai Hospital, Japan.
Fumisato SasakiDepartment of Gastroenterology, Ikeda Hospital, Japan.
Yoshitaka NakamuraDepartment of Gastroenterology, Kagoshima Prefectural Oshima Hospital, Japan.
Atsushi NanashimaDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Japan.
University of Miyazaki · JPFukuoka Tokushukai Hospital · JPIkeda Municipal Hospital · JPKagoshima Prefectural College · JPOita University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction Photodynamic therapy (PDT) is a salvage treatment for local failure after chemoradiotherapy for esophageal cancer. Salvage PDT is the treatment available for vulnerable patients with various comorbidities at risk of salvage esophagectomy. This study assessed the impact of the Charlson comorbidity index (CCI) on the outcomes of salvage PDT using talaporfin sodium (TS) for esophageal cancer. Metohds Consecutive patients with esophageal cancer who underwent salvage TS-PDT from 2016 to 2022 were included in this retrospective study. We investigated the local complete response (L-CR), progression-free survival (PFS) and overall survival (OS) and evaluated the relationship between the CCI and therapeutic efficacy. Results In total, 25 patients were enrolled in this study. Overall, 12 patients (48%) achieved an L-CR, and the 2-year PFS and OS rates were 24.9% and 59.4%, respectively. In a multivariate analysis, a CCI ≥1 (p=0.041) and deeper invasion (p=0.048) were found to be significant independent risk factors for not achieving an L-CR. To evaluate the efficacy associated with comorbidities, we divided the patients into the CCI=0 group (n=11) and the CCI ≥1 group (n=14). The rate of an L-CR (p=0.035) and the 2-year PFS (p=0.029) and OS (p=0.018) rates in the CCI ≥1 group were significantly lower than those in the CCI=0 group. Conclusion This study found that the CCI was negatively associated with the efficacy of salvage TS-PDT for esophageal cancer.

Indexed as

Esophageal NeoplasmsPhotochemotherapyPorphyrinsComorbidityHumansPhotosensitizing AgentsRetrospective StudiesSalvage TherapyTreatment OutcomePhotosensitizing AgentsPorphyrinsTalaporfincharlson comorbidity indexesophageal cancerphotodynamic therapytalaporfin sodium

Identifiers

PMID37558484
PMCPMC11045372
OpenAlexW4385654156

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.