Evidence map›Paper›PMID 37558205›Full record

ArticleMolecular oncology2023

Cadherin-11 increases tumor cell proliferation and metastatic potential via Wnt pathway activation.

Yayu Liu, Pedro Lei, Ronel Z Samuel, Anagha M Kashyap, Theodore Groth, Wiam Bshara, Sriram Neelamegham, Stelios T Andreadis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  7. Age-Driven Genetic and Epigenetic Heterogeneity in B-ALL.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yayu LiuDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Amherst, NY, USA.
Pedro LeiDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Amherst, NY, USA.ORCID 0000-0002-3550-8715
Ronel Z SamuelDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Amherst, NY, USA.
Anagha M KashyapDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Amherst, NY, USA.
Theodore GrothDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Amherst, NY, USA.
Wiam BsharaRoswell Park Comprehensive Cancer Center Pathology Resource Network, Buffalo, NY, USA.
Sriram NeelameghamDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Amherst, NY, USA.
Stelios T AndreadisDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Amherst, NY, USA.ORCID 0000-0001-9885-0457
University at Buffalo, State University of New York · USRoswell Park Comprehensive Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During epithelial-mesenchymal transition (EMT) in cancer progression, tumor cells switch cadherin profile from E-cadherin to cadherin-11 (CDH11), which is accompanied by increased invasiveness and metastatic activity. However, the mechanism through which CDH11 may affect tumor growth and metastasis remains elusive. Here, we report that CDH11 was highly expressed in multiple human tumors and was localized on the membrane, in the cytoplasm and, surprisingly, also in the nucleus. Interestingly, β-catenin remained bound to carboxy-terminal fragments (CTFs) of CDH11, the products of CDH11 cleavage, and co-localized with CTFs in the nucleus in the majority of breast cancer samples. Binding of β-catenin to CTFs preserved β-catenin activity, whereas inhibiting CDH11 cleavage led to β-catenin phosphorylation and diminished Wnt signaling, similar to CDH11 knockout. Our data elucidate a previously unknown role of CDH11, which serves to stabilize β-catenin in the cytoplasm and facilitates its translocation to the nucleus, resulting in activation of Wnt signaling, with subsequent increased proliferation, migration and invasion potential.

Indexed as

beta CateninNeoplasmsCadherinsCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionHumansWnt Signaling Pathwaybeta CateninCadherinsosteoblast cadherinbreast cancercadherin-11metastasisWnt signalingβ-catenin

Identifiers

PMID37558205
PMCPMC10552893
OpenAlexW4385691184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.