Evidence map›Paper›PMID 37557072›Full record

ArticleStem cell reports2023

Designing persuasive health education for patients seeking unproven stem cell interventions.

Omar Kawam, Xuan Zhu, David T Eton, Charlene Martin-Lillie, Lila J Finney Rutten, Shane Shapiro, Jon C Tilburt, Zubin Master

Abstract read
In one paragraph

Article in Stem cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Omar KawamBiomedical Ethics Research Program, Mayo Clinic, Rochester, MN, USA.
Xuan ZhuRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.
David T EtonRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.
Charlene Martin-LillieCenter for Regenerative Biotherapeutics, Mayo Clinic, Rochester, MN, USA.
Lila J Finney RuttenDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Shane ShapiroCenter for Regenerative Biotherapeutics, Mayo Clinic, Rochester, MN, USA; Department of Orthopedic Surgery, Mayo Clinic, Jacksonville, FL, USA.
Jon C TilburtBiomedical Ethics Research Program, Mayo Clinic, Rochester, MN, USA; Division of General Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Zubin MasterBiomedical Ethics Research Program, Mayo Clinic, Rochester, MN, USA; Center for Regenerative Biotherapeutics, Mayo Clinic, Rochester, MN, USA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA. Electronic address: master.zubin@mayo.edu.

Funding

Designing Effective Health Education for Patients Seeking Unregulated Stem Cell InterventionsR21AG068620 · NIA · MAYO CLINIC ROCHESTER · PI MASTER, ZUBIN · 2021 to 2022
$437k
Creation of the Novel Interventions Caution (NIC) Measure to Assess Patient Behavior Towards Unregulated Stem Cell InterventionsR03AG078555 · NIA · MAYO CLINIC ROCHESTER · PI LEE, MINJI K, MASTER, ZUBIN · 2022 to 2023
$159k
NIA NIH HHS R03 AG078555NIA NIH HHS R21 AG068620
6 · The paper itself

Abstract

Misinformation among clinics advertising unproven stem cell interventions (SCIs) is pervasive and has resulted in patient and societal harms. Most bioethics commentaries have centered on advancing regulatory approaches to curtail the supply side of the market, but insufficient attention has been paid to considering strategies influencing patient demand. In this article, we offer an ethical justification for the design and deployment of persuasive patient education on unproven SCIs and distinguish it from didactic and manipulative education frames. Persuasive education should aim to correct and inoculate against misinformation about unproven SCIs and instill a sense of caution among patients considering experimental interventions outside of a clinical trial. We outline various communication strategies to effectively correct or inoculate against SCI misinformation. The stem cell community needs to invest in understanding patients' informational sources, attitudes, and beliefs about SCIs to develop and implement evidence-based persuasive education to promote informed decision-making about these therapies.

Indexed as

CommunicationStem CellsHealth EducationHumans

Identifiers

PMID37557072
PMCPMC10444566

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.