Trial reportAmerican journal of respiratory and critical care medicine2023
A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated
Abstract readRandomized Controlled Trial
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Biofilm formation during pneumococcal carriage imprints naturally acquired humoral immunity.PLoS pathogens · 2026Article
- Disease-Attenuated Pneumococcal Biosynthesis Gene Mutants Invade the Mucosal Epithelium and Induce Innate Immunity.The Journal of infectious diseases · 2026Article
- Biofilm formation during pneumococcal carriage imprints naturally acquired humoral immunity.bioRxiv : the preprint server for biology · 2025Article
- Streptococcus pneumoniae epidemiology, pathogenesis and control.Nature reviews. Microbiology · 2025Review
- Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence ofmBio · 2024Article
- Genomic and panproteomic analysis of the development of infant immune responses to antigenically-diverse pneumococci.Nature communications · 2024Article
- Naturally acquired adaptive immunity toClinical & translational immunology · 2024Article
- Immunization with Attenuated Pneumococcal Strains Provides Protection against Pneumococcal Colonization in Humans.American journal of respiratory and critical care medicine · 2023Article
Corrections and comments
- Commented on by
Authors and funding
30 authors at 5 institutions in 3 countries.
Helen HillDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Elena MitsiDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.ORCID 0000-0001-7586-6050
Elissavet NikolaouDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Annie BlizardDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Sherin PojarDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Ashleigh HowardDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Angela Hyder-WrightDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Jack DevinDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Jesus ReinéDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Ryan RobinsonDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.ORCID 0000-0003-0871-4780
Carla SolórzanoDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Simon P JochemsDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.ORCID 0000-0002-4835-1032
Tinashe Kenny-NyazikaDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Elisa Ramos-SevillanoUCL Respiratory, Division of Medicine, University College London, London, United Kingdom.ORCID 0000-0003-0803-2755
Caroline M WeightDivision of Infection and Immunity, University College London, London, United Kingdom.
Chris MyerscoughDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Daniella McLenaghanDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Ben MortonDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.ORCID 0000-0002-6164-2854
Emily GibbonsDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Madlen FarrarDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Victoria RandlesDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Hassan BurhanLiverpool University Hospitals National Health Service Foundation Trust, Liverpool, United Kingdom.
Tao ChenDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Adam D ShandlingAntigen Discovery Inc, Irvine, California; and.
Joe J CampoAntigen Discovery Inc, Irvine, California; and.
Robert S HeydermanDivision of Infection and Immunity, University College London, London, United Kingdom.ORCID 0000-0003-4573-449X
Stephen B GordonDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Jeremy S BrownUCL Respiratory, Division of Medicine, University College London, London, United Kingdom.
Andrea M CollinsDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Daniela M FerreiraDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Liverpool School of Tropical Medicine · GBNational Health Service · GBUniversity College London · GBAntigen Discovery (United States) · USUniversity of Liverpool · GB
Funding
Medical Research Council MR/M011569/1Medical Research Council MR/N016874/1Medical Research Council MR/T016329/1
Abstract
PubMed holds no abstract for this paper.
Indexed as
Pneumococcal InfectionsStreptococcus pneumoniaeAdultAntibodies, BacterialHumansImmunizationImmunoglobulin GNosePneumococcal VaccinesVirulenceAntibodies, BacterialImmunoglobulin GPneumococcal Vaccinesattenuated strainshuman challengenasal administrationStreptococcus pneumoniae
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.