Evidence map›Paper›PMID 37556553›Full record

ArticleScience advances2023

Brain rhythms control microglial response and cytokine expression via NF-κB signaling.

Ashley Prichard, Kristie M Garza, Avni Shridhar, Christopher He, Sara Bitarafan, Alyssa Pybus, Yunmiao Wang, Emma Snyder, Matthew C Goodson, Tina C Franklin and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Temporal Interference Stimulation Enhances Neural Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Ashley PrichardWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.ORCID 0000-0001-7666-1444
Kristie M GarzaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.ORCID 0000-0003-1535-1957
Avni ShridharWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.ORCID 0000-0001-6717-3895
Christopher HeWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.ORCID 0000-0002-7733-1348
Sara BitarafanParker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Alyssa PybusWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
Yunmiao WangNeuroscience Graduate Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0001-8194-4166
Emma SnyderWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.ORCID 0009-0006-6648-2526
Matthew C GoodsonWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.ORCID 0000-0003-1282-8238
Tina C FranklinWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.ORCID 0000-0001-5958-3499
Dieter JaegerWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.ORCID 0000-0002-5122-1319
Levi B WoodWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.ORCID 0000-0002-4248-0888
Annabelle C SingerWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.ORCID 0000-0001-6003-0488
Georgia Institute of Technology · USThe Wallace H. Coulter Department of Biomedical Engineering · USEmory University · US

Funding

Research Training Program Plan on Cell and Tissue Engineering (CTEng)T32GM008433 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 1991 to 2021
$7.1M
Non-Invasive Methods to Drive Neural Activity with Millisecond Precision and to Recruit the Brain’s Immune CellsR01NS109226 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Annabelle Catherine Singer · 2018 to 2026
$2.7M
Hippocampal interneurons in novel memory formation in health and Alzheimer's diseaseRF1AG078736 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI SINGER, ANNABELLE CATHERINE · 2022 to 2025
$2.5M
Gamma Sensory Flicker as an Early Intervention for Alzheimer’s Disease: Mechanisms and Protective EffectsRF1NS109226 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI SINGER, ANNABELLE CATHERINE · 2023 to 2024
$2.2M
NIGMS NIH HHS T32 GM008433NINDS NIH HHS R01 NS109226NINDS NIH HHS RF1 NS109226
6 · The paper itself

Abstract

Microglia transform in response to changes in sensory or neural activity, such as sensory deprivation. However, little is known about how specific frequencies of neural activity, or brain rhythms, affect microglia and cytokine signaling. Using visual noninvasive flickering sensory stimulation (flicker) to induce electrical neural activity at 40 hertz, within the gamma band, and 20 hertz, within the beta band, we found that these brain rhythms differentially affect microglial morphology and cytokine expression in healthy animals. Flicker induced expression of certain cytokines independently of microglia, including interleukin-10 and macrophage colony-stimulating factor. We hypothesized that nuclear factor κB (NF-κB) plays a causal role in frequency-specific cytokine and microglial responses because this pathway is activated by synaptic activity and regulates cytokines. After flicker, phospho-NF-κB colabeled with neurons more than microglia. Inhibition of NF-κB signaling down-regulated flicker-induced cytokine expression and attenuated flicker-induced changes in microglial morphology. These results reveal a mechanism through which brain rhythms affect brain function by altering microglial morphology and cytokines via NF-κB.

Indexed as

BrainCytokinesMicrogliaNF-kappa BAnimalsSignal TransductionCytokinesNF-kappa B

Identifiers

PMID37556553
PMCPMC10411883
OpenAlexW4385690032

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.