ArticleScience advances2023
Genetically targeted chemical assembly of polymers specifically localized extracellularly to surface membranes of living neurons.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Multiomic proximity labeling in vivo by D-amino-acid-activated peroxidase reaction.Nature chemical biology · 2026Article
- Bioinspired organic materials for seamless neurohybrid interfaces: from material design to living electronics.Materials horizons · 2026Review
- Genetically targeted photocatalytic organic dyes for spatiotemporally controlled organic synthesis in specific living cells.Nature chemistry · 2026Article
- Suspension polymerization of bioelectronic interfaces on living cells.Materials horizons · 2026Article
- Engineered cell-biomimetic nanosystems for anti-inflammatory therapy: Targeting, neutralization and immunomodulation.Acta pharmaceutica Sinica. B · 2026Review
- Transforming healthcare through in-body bioelectronic systems.Nature communications · 2026Review
- Blood-catalyzed n-doped polymers for reversible optical neural control.Science (New York, N.Y.) · 2026Article
- Acoustic printing of conductive polymers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Materials and device strategies to enhance spatiotemporal resolution in bioelectronics.Nature reviews. Materials · 2025Article
- Implantable bioelectronic devices for photoelectrochemical and electrochemical modulation of cells and tissues.Nature reviews bioengineering · 2025Article
- Bio-inspired electronics: Soft, biohybrid, and "living" neural interfaces.Nature communications · 2025Review
- From synthetic vesicles to living cells: Anchoring conducting polymers to cell membrane.Science advances · 2024Article
- Applications of synthetic polymers directed toward living cells.Nature synthesis · 2024Article
- Using Chemistry To Recreate the Complexity of the Extracellular Matrix: Guidelines for Supramolecular Hydrogel-Cell Interactions.Journal of the American Chemical Society · 2024Review
- Blood-Catalyzed Polymerization Creates Conductive Polymer in Live Zebrafish.Research square · 2024Article
- Exploring Present and Future Directions in Nano-Enhanced Optoelectronic Neuromodulation.Accounts of chemical research · 2024Review
- Genetically targeted chemical assembly of polymers specifically localized extracellularly to surface membranes of living neurons.Science advances · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Multicellular biological systems, particularly living neural networks, exhibit highly complex organization properties that pose difficulties for building cell-specific biocompatible interfaces. We previously developed an approach to genetically program cells to assemble structures that modify electrical properties of neurons in situ, opening up the possibility of building minimally invasive cell-specific structures and interfaces. However, the efficiency and biocompatibility of this approach were challenged by limited membrane targeting of the constructed materials. Here, we design a method for highly localized expression of enzymes targeted to the plasma membrane of primary neurons, with minimal intracellular retention. Next, we show that polymers synthesized in situ by this approach form dense extracellular clusters selectively on the targeted cell membrane and that neurons remain viable after polymerization. Last, we show generalizability of this method across a range of design strategies. This platform can be readily extended to incorporate a broad diversity of materials onto specific cell membranes within tissues and may further enable next-generation biological interfaces.
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Registered trials
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