Evidence map›Paper›PMID 37555881›Full record

SynthesisDigestive diseases and sciences2023

Technical Success, Sample Adequacy, and Complications of  Pediatric Transjugular Liver Biopsy: A Systematic Review and Meta-Analysis.

Karen Smayra, Shahid Miangul, Nathanael Yap, Ao Shi, Fatma Abdulsalam, Maamoun Adra, Hayato Nakanishi, Jake Ball, Tara A Betts, Christian A Than and 1 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Digestive diseases and sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Pediatric endoscopic ultrasound-guided liver biopsy: 3-year experience.Journal of pediatric gastroenterology and nutrition · 2025
    Article
  4. Nontargeted Liver Biopsy in Children.Seminars in interventional radiology · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Karen SmayraSt George's University of London, London, SW17 0RE, UK.
Shahid MiangulSt George's University of London, London, SW17 0RE, UK.
Nathanael YapSt George's University of London, London, SW17 0RE, UK.
Ao ShiSt George's University of London, London, SW17 0RE, UK.
Fatma AbdulsalamSt George's University of London, London, SW17 0RE, UK.
Maamoun AdraSt George's University of London, London, SW17 0RE, UK.
Hayato NakanishiSt George's University of London, London, SW17 0RE, UK.
Jake BallDepartment of Medical Imaging, John Hunter Hospital, Newcastle, Australia.
Tara A BettsCardiff and Vale University Health Board, Heath Park, Cardiff, CF14 4XW, UK.
Christian A ThanSt George's University of London, London, SW17 0RE, UK. c.than@uq.edu.au.ORCID http://orcid.org/0000-0002-4193-9925
Aneeta ParthipunGuy's, St. Thomas' and Evelina Children's Hospital, Westminster Bridge Road, London, SE1 7EH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransjugular liver biopsy (TJLB) procedurally samples liver tissue through the internal jugular vein. It is indicated in the presence of coagulopathies and/or ascites.

aimsThis meta-analysis aimed to assess the safety and efficacy of TJLB in children.

methodsA literature search of several databases was conducted from inception to August 2022. Eligible studies reported pediatric patients (< 18 years old) who underwent TJLB. The pooled proportion was analyzed using a random-effects model. This review was registered in PROSPERO (CRD42022354421).

resultsFrom 921 initial studies screened, eight met the eligibility criteria, with a total of 361 pediatric patients who underwent 374 TJLBs. All eight studies reported pooled rates of technical success at 99.1% (95% CI 0.982, 1.001; I

conclusionPediatric TJLB demonstrates high rates of technical success and adequate liver core biopsy samples, with a low rate of complications. These results suggest that TJLB is an effective method for diagnostic yield and postprocedural outcomes, especially in patients with preexisting coagulopathies and ascites where percutaneous liver biopsy is contraindicated. Additional studies evaluating larger groups of pediatric patients may provide further support for the use of TJLB in this population.

Indexed as

Digestive System Surgical ProceduresLiver DiseasesAdolescentAscitesBiopsyBiopsy, NeedleChildHumansLiverPainRetrospective StudiesChildrenComplicationsLiver biopsyPediatricsTransjugular

Identifiers

PMID37555881
PMCPMC10517041

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.