ArticleeLife2023
An open-source platform for head-fixed operant and consummatory behavior.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Drug self-administration in head-fixed mice.Nature protocols · 2026Review
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- Adenosine APsychopharmacology · 2026Article
- EthoPy provides an accessible platform for reproducible behavioral neuroscience.Cell reports methods · 2026Article
- Article
- Identification of a stress-sensitive endogenous opioid-containing neuronal population in the paranigral ventral tegmental area.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Medial nucleus accumbens dopamine receptors modulate motivation for wheel running in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Histamine Dynamics During Ingestive Behavior Measured by the Novel Biosensor HisLightG.Journal of neurochemistry · 2025Article
- Article
- Article
- Rapid fluctuations in histamine associated with intake of nutritive and non-nutritive solutions.bioRxiv : the preprint server for biology · 2025Article
- Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms.eLife · 2025Article
- An Open-Source 3D-Printable Platform for Testing Head-Fixed Cognitive Flexibility in Rodents.eNeuro · 2025Article
- Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release.Nature communications · 2024Article
- Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release.bioRxiv : the preprint server for biology · 2024Article
- A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging.Neuropharmacology · 2024Article
- Article
- Review
- Studying behavior under constrained movement.eLife · 2023Article
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Authors and funding
9 authors.
Funding
Abstract
Head-fixed behavioral experiments in rodents permit unparalleled experimental control, precise measurement of behavior, and concurrent modulation and measurement of neural activity. Here, we present OHRBETS (Open-Source Head-fixed Rodent Behavioral Experimental Training System; pronounced 'Orbitz'), a low-cost, open-source platform of hardware and software to flexibly pursue the neural basis of a variety of motivated behaviors. Head-fixed mice tested with OHRBETS displayed operant conditioning for caloric reward that replicates core behavioral phenotypes observed during freely moving conditions. OHRBETS also permits optogenetic intracranial self-stimulation under positive or negative operant conditioning procedures and real-time place preference behavior, like that observed in freely moving assays. In a multi-spout brief-access consumption task, mice displayed licking as a function of concentration of sucrose, quinine, and sodium chloride, with licking modulated by homeostatic or circadian influences. Finally, to highlight the functionality of OHRBETS, we measured mesolimbic dopamine signals during the multi-spout brief-access task that display strong correlations with relative solution value and magnitude of consumption. All designs, programs, and instructions are provided freely online. This customizable platform enables replicable operant and consummatory behaviors and can be incorporated with methods to perturb and record neural dynamics in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.