Evidence map›Paper›PMID 37555211›Full record

ArticleJournal of applied crystallography2023

Revealing cholesterol effects on PEGylated HSPC liposomes using AF4-MALS and simultaneous small- and wide-angle X-ray scattering.

Ting-Wei Hsu, Ching-Hsun Yang, Chun-Jen Su, Yin-Tzu Huang, Yi-Qi Yeh, Kuei-Fen Liao, Tien-Chang Lin, Orion Shih, Ming-Tao Lee, An-Chung Su and 1 more

Abstract read
In one paragraph

Article in Journal of applied crystallography, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ting-Wei HsuNational Synchrotron Radiation Research Center, 101 Hsin-Ann Road, Hsinchu Science Park, Hsinchu 300094, Taiwan.ORCID https://orcid.org/0000-0003-0523-1118
Ching-Hsun YangNational Synchrotron Radiation Research Center, 101 Hsin-Ann Road, Hsinchu Science Park, Hsinchu 300094, Taiwan.
Chun-Jen SuNational Synchrotron Radiation Research Center, 101 Hsin-Ann Road, Hsinchu Science Park, Hsinchu 300094, Taiwan.
Yin-Tzu HuangNational Synchrotron Radiation Research Center, 101 Hsin-Ann Road, Hsinchu Science Park, Hsinchu 300094, Taiwan.
Yi-Qi YehNational Synchrotron Radiation Research Center, 101 Hsin-Ann Road, Hsinchu Science Park, Hsinchu 300094, Taiwan.ORCID https://orcid.org/0000-0002-2387-3600
Kuei-Fen LiaoNational Synchrotron Radiation Research Center, 101 Hsin-Ann Road, Hsinchu Science Park, Hsinchu 300094, Taiwan.
Tien-Chang LinDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan.
Orion ShihNational Synchrotron Radiation Research Center, 101 Hsin-Ann Road, Hsinchu Science Park, Hsinchu 300094, Taiwan.ORCID https://orcid.org/0000-0002-0610-6856
Ming-Tao LeeNational Synchrotron Radiation Research Center, 101 Hsin-Ann Road, Hsinchu Science Park, Hsinchu 300094, Taiwan.
An-Chung SuDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan.
U-Ser JengNational Synchrotron Radiation Research Center, 101 Hsin-Ann Road, Hsinchu Science Park, Hsinchu 300094, Taiwan.ORCID https://orcid.org/0000-0002-2247-5061

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liposome development is of great interest owing to increasing requirements for efficient drug carriers. The structural features and thermal stability of such liposomes are crucial in drug transport and delivery. Reported here are the results of the structural characterization of PEGylated liposomes via small- and wide-angle X-ray scattering and an asymmetric flow field-flow fractionation (AF4) system coupled with differential refractive-index detection, multi-angle light scattering (MALS) and dynamic light scattering. This integrated analysis of the exemplar PEGylated liposome formed from hydrogenated soy phosphatid-yl-choline (HSPC) with the addition of cholesterol reveals an average hydro-dynamic radius (

Indexed as

AF4-MALSasymmetric flow field-flow fractionationcholesterol effectsdrug-carrying liposomesmulti-angle light scatteringphospho­lipid membranesSAXS–WAXSsmall-angle X-ray scatteringwide-angle X-ray scattering

Identifiers

PMID37555211
PMCPMC10405602

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.