ArticleHealth science reports2023
Challenges and solutions in clinical research during the COVID-19 pandemic: A narrative review.
Article in Health science reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- The ManageHF Just-in-Time Adaptive Mobile App Interventions to Promote Self-Management and Improve Outcomes in Heart Failure: Randomized Controlled Trial.JMIR mHealth and uHealth · 2026Trial
- Can a participant-referred 'study buddy' increase retention of rural people who use drugs in research? A multi-site, randomized trial.Addiction (Abingdon, England) · 2026Trial
- Quality Improvement Intervention to Increase Sleep Apnea Diagnostic Testing After Stroke and Transient Ischemic Attack: A Cluster Randomized Trial.JAMA network open · 2025Trial
- Effect of expressive writing on the sexual self-concept in men with multiple sclerosis: a randomized clinical controlled trial.BMC neurology · 2025Trial
- Melatonin for preventing postoperative delirium in elderly patients: A multicenter randomized placebo-controlled pilot study.Medicine · 2025Trial
- Prediabetes and cardiovascular risk factors: the effectiveness of a guided self-determination counselling approach in primary health care, a randomized controlled trial.BMC public health · 2024Trial
- Personal variation in the palatability and side effects of liquid clindamycin among children.Pediatric research · 2026Article
- Research In Your Mailbox: Remote Blood Self-sampling Enables Participation of Underserved Populations in Longitudinal Studies.medRxiv : the preprint server for health sciences · 2026Article
- Deliberating at a Distance: Evaluating the Feasibility of a Fully Virtual CHAT Exercise Among Low-Income Communities.Health expectations : an international journal of public participation in health care and health policy · 2025Article
- The impact of preclinical education on operative and restorative skills in dental students: a survey-based evaluation.BMC medical education · 2025Article
- Flagged for Fraud: Lessons From 3 Case Studies on Detecting Inauthentic Participants in Online Research.Journal of medical Internet research · 2025Article
- Validation of an Asthma Knowledge Tool to Assess the Efficacy of Comprehensive Asthma Education.Pediatric pulmonology · 2025Article
- Insights from recruiting individuals with mild dementia and care partners for a multi-site oral hygiene intervention.Aging and health research · 2025Article
- Quantitative Assessment of a Novel Device Designed for Patient-centric Sampling of Dried Plasma Using Targeted Proteomics.Analytical chemistry · 2025Article
- Long-Term Effects of COVID-19 on Women's Reproductive Health and Its Association with Autoimmune Diseases, Including Multiple Sclerosis.Journal of clinical medicine · 2025Review
- Research protocol design and implementation of a hybrid no-touch and low-touch prospective observational study during the COVID-19 public health emergency: the VISION study.BMJ public health · 2025Article
- A Mobile Health Intervention in Caregivers of Patients Undergoing Hematopoietic Cell Transplantation: A Randomized Controlled Trial to Examine Health-Related Quality of Life.BMC digital health · 2025Article
- Community partners identified implementation considerations prior to a randomized clinical trial for uncontrolled asthma in Federally Qualified Health Centers.Journal of clinical and translational science · 2025Article
- Ethical issues and the role of the ethics committees during COVID-19 research in pandemic era: a focus on an Italian ethics committee.Frontiers in public health · 2025Article
- Public health emergency accelerated research response-the Clinical and Translational Science Institute of Southeast Wisconsin COVID-19 research initiative.Frontiers in public health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: The COVID-19 pandemic has presented significant challenges to clinical research, necessitating the adoption of innovative and remote methods to conduct studies. This study aimed to investigate these challenges and propose solutions for conducting clinical research during the pandemic. Methods: A narrative review was conducted (approval ID: IR.AMS.REC.1401.029), utilizing keyword searches in PubMed and Web of Science (WOS) citation index expanded (SCI-EXPANDED) from January 2020 to January 2023. Keywords included COVID-19, clinical research, barriers, obstacles, facilitators and enablers. Results: Out of 2508 records retrieved, 43 studies were reviewed, providing valuable insights into the challenges and corresponding solutions for conducting clinical research during the COVID-19 pandemic. The identified challenges were categorized into four main groups: issues related to researchers or investigators, issues related to participants and ethical concerns, administrative issues, and issues related to research implementation. To address these challenges, multiple strategies were proposed, including remote monitoring through phone or video visits, online data collection and interviews to minimize in-person contact, development of virtual platforms for participant interaction and questionnaire completion, consideration of financial incentives, adherence to essential criteria such as inclusion and exclusion parameters, participant compensation, and risk assessment for vulnerable patients. Conclusion: The COVID-19 pandemic has significantly impacted clinical research, requiring the adaptation and enhancement of existing research structures. Although remote methods and electronic equipment have limitations, they hold promise as effective solutions during this challenging period.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.