Evidence map›Paper›PMID 37554946›Full record

ArticleFujita medical journal2023

Similarities in rotavirus vaccine viral shedding and immune responses in pairs of twins.

Yasuko Enya, Hiroyuki Hiramatsu, Masaru Ihira, Ryota Suzuki, Yuki Higashimoto, Yusuke Funato, Kei Kozawa, Hiroki Miura, Masafumi Miyata, Yoshiki Kawamura and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fujita medical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yasuko EnyaFaculty of Clinical Engineering, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Hiroyuki HiramatsuDepartment of Clinical Pharmacy, Fujita Health University Hospital, Toyoake, Aichi, Japan.
Masaru IhiraFaculty of Clinical Science for Biological Monitoring, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Ryota SuzukiDepartment of Clinical Pharmacy, Fujita Health University Hospital, Toyoake, Aichi, Japan.
Yuki HigashimotoFaculty of Cellular and Molecular Biology, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Yusuke FunatoDepartment of Pediatrics, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Kei KozawaDepartment of Pediatrics, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Hiroki MiuraDepartment of Pediatrics, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Masafumi MiyataDepartment of Pediatrics, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Yoshiki KawamuraDepartment of Pediatrics, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Takuma IshiharaInnovative and Clinical Research Promotion Center, Gifu University Hospital, Gifu, Gifu, Japan.
Koki TaniguchiDepartment of Virology and Parasitology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Satoshi KomotoDepartment of Virology and Parasitology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Tetsushi YoshikawaDepartment of Pediatrics, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Intestinal rotavirus (RV) vaccine replication and host immune response are suggested to be affected by several factors, including maternal antibodies, breastfeeding history, and gut microbiome, which are thought to be similar in pairs of twins. The aim of this study was to determine whether viral shedding from the fecal RV vaccine strain Rotarix Methods: Quantitative reverse transcription polymerase chain reaction specific to RV vaccine strain RV1 was used to monitor fecal RV1 viral shedding. RV IgG and IgA titers were measured using an in-house enzyme-linked immunosorbent assay. Fecal RV1 viral shedding and immune responses were compared between twins and singletons with mixed effects and fixed effects models. Results: A total of 347 stool and 54 blood samples were collected from four pairs of twins and twelve singletons during the observation period. Although the kinetics of fecal RV1 viral shedding and immune responses differed among vaccinated individuals, they appeared to be similar within twin pairs. RV shedding after the first dose ( Conclusions: The similarity of RV vaccine viral replication in intestine and host immune responses in twin pairs was demonstrated using statistical analysis.

Indexed as

Fecal viral sheddingRotavirus IgARotavirus IgGRotavirus vaccineTwins

Identifiers

PMID37554946
PMCPMC10405898

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.