Evidence map›Paper›PMID 37554925›Full record

ReviewJHEP reports : innovation in hepatology2023

Enhancing interventions for prevention of mother-to-child- transmission of hepatitis B virus.

Philippa C Matthews, Ponsiano Ocama, Su Wang, Manal El-Sayed, Anna Turkova, Deborah Ford, Judith Torimiro, Ana Cristina Garcia Ferreira, Angélica Espinosa Miranda, Fernando Pio De La Hoz Restrepo and 7 more

Open access · goldAbstract readReview
In one paragraph

Review in JHEP reports : innovation in hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  5. Trial
  6. Article
  7. Response to correspondence on "Effective prevention of hepatitis B transmission from pregnant women to babies in a real-life setting in India".Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 9 countries.

Philippa C MatthewsThe Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Ponsiano OcamaDepartment of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Su WangCooperman Barnabas Medical Center, Florham Park, NJ, USA.
Manal El-SayedDepartment of Paediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Anna TurkovaMedical Research Council Clinical Trials Unit, University College London, 90 High Holborn, London WC1V 6LJ, UK.
Deborah FordMedical Research Council Clinical Trials Unit, University College London, 90 High Holborn, London WC1V 6LJ, UK.
Judith TorimiroChantal Biya International Reference Centre for Research on Prevention and Management of HIV/AIDS (CIRCB), Yaounde, Cameroon.
Ana Cristina Garcia FerreiraMinistry of Health, Health Surveillance Department, Department of Chronic Diseases and Sexually Transmitted Infections, SRTVN Quadra 701, Lote D, PO700 Building, CEP: 70719-040, Brasília/DF, Brazil.
Angélica Espinosa MirandaMinistry of Health, Health Surveillance Department, Department of Chronic Diseases and Sexually Transmitted Infections, SRTVN Quadra 701, Lote D, PO700 Building, CEP: 70719-040, Brasília/DF, Brazil.
Fernando Pio De La Hoz RestrepoUniversidad Nacional de Colombia, Bogotá, Colombia.
Emmanuel SerembaDepartment of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Robinson MbuFaculty of Medicine and Biomedical Sciences, University of Yaounde, Yaounde, Cameroon.
Calvin Q PanDivision of Gastroenterology and Hepatology, NYU Langone Health, NYU Grossman School of Medicine, NY, USA.
Homie RazaviCenter for Disease Analysis Foundation, 1120 W South Boulder Rd Suite 102, Lafayette, CO 80026, USA.
Geoffrey DusheikoLiver Unit, King's College Hospital, Denmark Hill, London SE5 9RS, UK.
C Wendy SpearmanDivision of Hepatology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
Saeed HamidDepartment of Medicine, Aga Khan University, Karachi, Pakistan.
Makerere University · UGMinistério da Saúde · BRUniversité de Yaoundé I · CMUniversity College London · GBAga Khan University · PKAin Shams University · EGCenter for Disease Analysis · USKing's College Hospital · GBSaint Barnabas Medical Center · USUniversidad Nacional de Colombia · COUniversity College Hospital · GBUniversity of Cape Town · ZA

Funding

Medical Research Council MC_UU_00004/03
6 · The paper itself

Abstract

Prevention of mother-to-child transmission of hepatitis B virus (HBV) infection is a cornerstone of efforts to support progress towards elimination of viral hepatitis. Current guidelines recommend maternal screening, antiviral therapy during the third trimester of high-risk pregnancies, universal and timely HBV birth dose vaccination, and post-exposure prophylaxis with hepatitis B immunoglobulin for selected neonates. However, serological and molecular diagnostic testing, treatment and HBV vaccination are not consistently deployed, particularly in many high endemicity settings, and models predict that global targets for reduction in paediatric incidence will not be met by 2030. In this article, we briefly summarise the evidence for current practice and use this as a basis to discuss areas in which prevention of mother-to-child transmission can potentially be enhanced. By reducing health inequities, enhancing pragmatic use of resources, filling data gaps, developing advocacy and education, and seeking consistent investment from multilateral agencies, significant advances can be made to further reduce vertical transmission events, with wide health, societal and economic benefits.

Indexed as

birth doseeliminationHBIGHBVhepatitis B virusPMTCTpreventiontenofovirtransmissionvaccinationvertical transmission

Identifiers

PMID37554925
PMCPMC10405098
OpenAlexW4366824743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.