Evidence map›Paper›PMID 37554762›Full record

ArticleFrontiers in endocrinology2023

Parathyroid gland detection using an intraoperative autofluorescence handheld imager - early feasibility study.

Khalid Mohamed Ali, Samantha A Wolfe, Nimesh V Nagururu, Stefanie Seo, Sung-Min Han, Yoseph Kim, Eugene Oh, Dong-Yun Kim, Bo Ning, Seung Yup Lee and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06939946 (Early Feasibility Study on Intraoperative Parathyroid Gland), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06939946 phase1terminatednot on this map

Early Feasibility Study on Intraoperative Parathyroid Gland (PTG) Identification Using a Hand-Held Imager (HHI)

TypeinterventionalSponsorOPTOSURGICAL, LLCRan2023 to 2025Enrolled20ConditionsThyroid Disease, Thyroid Surgery, Parathyroid GlandArmsParathyroid auto-fluorescence imaging, Indocyanine green
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Khalid Mohamed AliDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Samantha A WolfeDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Nimesh V NagururuDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Stefanie SeoDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Sung-Min Hani2KIE LLC, Gaithersburg, MD, United States.
Yoseph KimDepartment of Research and Development, Optosurgical, LLC, Columbia, MD, United States.
Eugene OhDepartment of Research and Development, Optosurgical, LLC, Columbia, MD, United States.
Dong-Yun KimOffice of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Bo NingSheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, United States.
Seung Yup LeeDepartment of Electrical and Computer Engineering, Kennesaw State University, Marietta, GA, United States.
Richard Jaepyeong ChaDepartment of Research and Development, Optosurgical, LLC, Columbia, MD, United States.
Ralph P TufanoDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Jonathon O RussellDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Johns Hopkins Medicine · USChildren's National · USJohns Hopkins University · USKennesaw State University · USNational Institutes of Health · USSarasota Memorial Health Care System · US

Funding

hANDY-i(TM): A non-invasive, dual-sensor handheld imager for intraoperative preservation of parathyroid glandsR44EB030874 · NIBIB · OPTOSURGICAL, LLC · PI CHA, RICHARD JAEPYEONG, OH, EUGENE · 2022 to 2023
$1.7M
hANDY-i(TM): A non-invasive, dual-sensor handheld imager for intraoperative preservation of parathyroid glandsR43EB030874 · NIBIB · OPTOSURGICAL, LLC · PI CHA, RICHARD JAEPYEONG, TUFANO, RALPH P · 2020 to 2020
$252k
NIBIB NIH HHS R43 EB030874NIBIB NIH HHS R44 EB030874
6 · The paper itself

Abstract

Introduction: Parathyroid glands may be compromised during thyroid surgery which can lead to hypoparathyroidism and hypocalcemia. Identifying the parathyroid glands relies on the surgeon's experience and the only way to confirm their presence was through tissue biopsy. Near infrared autofluorescence technology offers an opportunity for real-time, non-invasive identification of the parathyroid glands. Methods: We used a new research prototype (hANDY-I) developed by Optosurgical, LLC. It offers coaxial excitation light and a dual-Red Green Blue/Near Infrared sensor that guides anatomical landmarks and can aid in identification of parathyroid glands by showing a combined autofluorescence and colored image simultaneously. Results: We tested the imager during 23 thyroid surgery cases, where initial clinical feasibility data showed that out of 75 parathyroid glands inspected, 71 showed strong autofluorescence signal and were correctly identified (95% accuracy) by the imager. Conclusions: The hANDY-I prototype demonstrated promising results in this feasibility study by aiding in real-time visualization of the parathyroid glands. However, further testing by conducting randomized clinical trials with a bigger sample size is required to study the effect on levels of hypoparathyroidism and hypocalcemia.

Indexed as

HypocalcemiaHypoparathyroidismFeasibility StudiesHumansOptical ImagingParathyroid GlandsThyroidectomyhypocalcaemiahypoparathryroidismnear infrared autofluorescenceparathyroid autofluorescence (AF)parathyroid glands (PG)thyroid surgery

Identifiers

PMID37554762
PMCPMC10405624
OpenAlexW4385216627

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.