Evidence map›Paper›PMID 37554719›Full record

ArticleAnnals of cardiothoracic surgery2023

Biomechanics and clinical outcomes of various conduit configurations in valve sparing aortic root replacement.

Yuanjia Zhu, Matthew H Park, Pearly K Pandya, Charles J Stark, Danielle M Mullis, Sabrina K Walsh, Joo Young Kim, Catherine A Wu, Basil M Baccouche, Seung Hyun Lee and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of cardiothoracic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Yuanjia ZhuDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Matthew H ParkDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Pearly K PandyaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Charles J StarkDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Danielle M MullisDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Sabrina K WalshDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Joo Young KimDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Catherine A WuDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Basil M BaccoucheDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Seung Hyun LeeDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Abakar S BarakaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Hyunchel JooDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Shin YajimaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Stefan EldeDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Y Joseph WooDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Stanford University · USThe University of Osaka · JPYonsei University · KR

Funding

Stanford Integrated Cardiovascular/Pulmonary Residency Research Training ProgramR38HL143615 · NHLBI · STANFORD UNIVERSITY · PI Michael Peter Fischbein, Marlene Rabinovitch · 2020 to 2026
$2.2M
NHLBI NIH HHS R38 HL143615
6 · The paper itself

Abstract

Background: Several conduit configurations, such as straight graft (SG), Valsalva graft (VG), anticommissural plication (ACP), and the Stanford modification (SMOD) technique, have been described for the valve-sparing aortic root replacement (VSARR) procedure. Prior Methods: Porcine aortic roots with coronary arteries were explanted (n=5) and underwent VSARR using SG, VG, ACP, and SMOD for evaluation in an Results: SG demonstrated lower rapid leaflet opening velocity compared with VG (P=0.001) and SMOD (P=0.045) in the left coronary cusp (LCC), lower rapid leaflet closing velocity compared with VG (P=0.04) in the right coronary cusp (RCC), and lower relative opening force compared with ACP (P=0.04) in the RCC. The flutter frequency was lower in baseline compared with VG (P=0.02) and in VG compared with ACP (P=0.03) in the LCC. Left coronary artery mean flow was higher in SG compared with SMOD (P=0.02) and ACP (P=0.05). Clinically, operations using SG compared with sinus-containing graft was associated with shorter aortic cross-clamp and cardiopulmonary bypass time (P<0.001, <0.001). Conclusions: SG demonstrated hemodynamics and biomechanics most closely recapitulating those from the native root with significantly shorter intraoperative times compared with repair using sinus-containing graft. Future

Indexed as

biomechanicsconduit configurationscoronary flowleaflet kinematicsValve-sparing aortic root replacement (VSARR)

Identifiers

PMID37554719
PMCPMC10405339
OpenAlexW4385308442

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.