Evidence map›Paper›PMID 37554586›Full record

ArticleNational science review2023

Nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes.

Jun Lin, Liang Dong, Yi-Ming Liu, Yi Hu, Chen Jiang, Ke Liu, Liu Liu, Yong-Hong Song, Mei Sun, Xing-Cheng Xiang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in National science review, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jun LinDepartment of Neurosurgery, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Molecular Medicine, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230027, China.
Liang DongDepartment of Neurosurgery, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Molecular Medicine, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230027, China.
Yi-Ming LiuDepartment of Neurosurgery, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Molecular Medicine, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230027, China.
Yi HuDepartment of Neurosurgery, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Molecular Medicine, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230027, China.
Chen JiangDepartment of Neurosurgery, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Molecular Medicine, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230027, China.
Ke LiuDepartment of Neurosurgery, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Molecular Medicine, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230027, China.
Liu LiuDepartment of Neurosurgery, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Molecular Medicine, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230027, China.
Yong-Hong SongAnhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, China.
Mei SunDepartment of Neurosurgery, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Molecular Medicine, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230027, China.
Xing-Cheng XiangThe WUT-AMU Franco-Chinese Institute, Wuhan University of Technology, Wuhan 430070, China.
Kun QuDepartment of Neurosurgery, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Molecular Medicine, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230027, China.ORCID https://orcid.org/0000-0002-5555-8437
Yang LuAnhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, China.
Long-Ping WenDepartment of Neurosurgery, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Molecular Medicine, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230027, China.
Shu-Hong YuDepartment of Neurosurgery, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Molecular Medicine, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230027, China.ORCID https://orcid.org/0000-0003-3732-1011

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation of inflammasomes-immune system receptor sensor complexes that selectively activate inflammatory responses-has been associated with diverse human diseases, and many nanomedicine studies have reported that structurally and chemically diverse inorganic nanomaterials cause excessive inflammasome activation. Here, in stark contrast to reports of other inorganic nanomaterials, we find that nickel-cobalt alloy magnetic nanocrystals (NiCo NCs) actually inhibit activation of NLRP3, NLRC4 and AIM2 inflammasomes. We show that NiCo NCs disrupt the canonical inflammasome ASC speck formation process by downregulating the lncRNA

Indexed as

colitisinflammasomeNeat1nickel-cobalt nanoparticleNLRP3

Identifiers

PMID37554586
PMCPMC10406336

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.