ArticleClinical interventions in aging2023
Impaired Sensitivity to Thyroid Hormones is Associated with Mild Cognitive Impairment in Euthyroid Patients with Type 2 Diabetes.
Article in Clinical interventions in aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Cognitive Impairment and Associated Factors Among Adult Hyperthyroid Patients at Bale Zone Hospitals, Southeast Ethiopia, 2024: Institution-Based Cross-Sectional Study.Health science reports · 2026Article
- Association between thyroid dysfunction and cognitive impairment in type 2 diabetes mellitus: A cross-sectional study.Journal of diabetes investigation · 2026Article
- Impaired sensitivity to thyroid hormones is associated with frailty in older patients with cardiometabolic disease.BMC geriatrics · 2025Article
- Association between sensitivity to thyroid hormone indices and frailty in the elderly: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Elevated mitochondrial DNA copy number in euthyroid individuals with impaired peripheral sensitivity to thyroid hormones.Frontiers in endocrinology · 2025Article
- Characterizing cognitive phenotypes and clinical correlates in type 2 diabetes using fuzzy clustering and decision tree analysis.Scientific reports · 2024Article
- Moderating effects of body composition biomarkers on the relationship between thyroid hormones and cognitive performance in euthyroid older adults: insights from NHANES data.Frontiers in endocrinology · 2024Article
- Thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort.Frontiers in endocrinology · 2023Article
- Impaired Sensitivity to Thyroid Hormones Is Associated with Mild Cognitive Impairment in Euthyroid Patients with Type 2 Diabetes [Letter].Clinical interventions in aging · 2023Article
- Impaired Sensitivity to Thyroid Hormones is Associated with Mild Cognitive Impairment in Euthyroid Patients with Type 2 Diabetes [Response to Letter].Clinical interventions in aging · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The prevalence of mild cognitive impairment (MCI) in patients with type 2 diabetes (T2D) is rapidly increasing. Thyroid hormones are key regulators of cognitive function in adults. The purpose of this study was to investigate the relationship between thyroid hormone sensitivity and MCI in euthyroid T2D patients. Patients and Methods: A total of 400 euthyroid T2D patients were enrolled in this cross-sectional study, including 218 patients with normal cognition and 182 MCI patients. The Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive function. The free triiodothyronine to free thyroxine (FT3/FT4) ratio was calculated as a measure of peripheral sensitivity to thyroid hormones; the thyroid-stimulating hormone index (TSHI), thyrotrophic thyroxine resistance index (TT4RI) and thyroid feedback quantile-based index (TFQI) were calculated as measures of central sensitivity to thyroid hormones. Linear regression analysis and logistic regression analysis were performed to explore the relationships between these indices of thyroid hormone sensitivity and the MoCA score and MCI, respectively. Results: Compared with the normal cognitive function group, patients in the MCI group had higher TSHI, TT4RI and TFQI but a lower FT3/FT4 ratio ( Conclusion: Impaired sensitivity to thyroid hormones is associated with MCI in euthyroid T2D patients.
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