Evidence map›Paper›PMID 37554463›Full record

ArticleiScience2023

Reinvestigating the clinical relevance of the m

Jonas Koch, Manuel Neuberger, Martina Schmidt-Dengler, Jinyun Xu, Vitor Coutinho Carneiro, Jörg Ellinger, Maximilian C Kriegmair, Philipp Nuhn, Philipp Erben, Maurice Stephan Michel and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. The bladder cancer mEMBO reports · 2026
    Article
  2. mbioRxiv : the preprint server for biology · 2026
    Article
  3. Unraveling the dual role of METTL3-mediated mCancer biology & therapy · 2025
    Review
  4. Loss of YTHDC1 mExperimental & molecular medicine · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jonas KochDivision of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany.
Manuel NeubergerDepartment of Urology and Urosurgery, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Martina Schmidt-DenglerInstitute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-Universität, 55128 Mainz, Germany.
Jinyun XuDivision of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany.
Vitor Coutinho CarneiroDivision of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany.
Jörg EllingerDepartment of Urology, University Hospital Bonn, 53127 Bonn, Germany.
Maximilian C KriegmairDepartment of Urology and Urosurgery, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Philipp NuhnDepartment of Urology and Urosurgery, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Philipp ErbenDepartment of Urology and Urosurgery, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Maurice Stephan MichelDepartment of Urology and Urosurgery, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Mark HelmInstitute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-Universität, 55128 Mainz, Germany.
Manuel Rodríguez-ParedesDivision of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany.
Malin NientiedtDepartment of Urology and Urosurgery, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Frank LykoDivision of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

METTL3 is the major writer of N6-Methyladenosine (m

Indexed as

Biological sciencesCancer systems biologyEpigeneticsMolecular biologyMolecular mechanism of gene regulationNatural sciencesOncologySystems biology

Identifiers

PMID37554463
PMCPMC10405067

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.