ArticleiScience2023
Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases.
Abstract read
In one paragraph
Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed.
- HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial.Nature communications · 2025Trial
- Decoding the glycan shield: Immune recognition and response to the HIV-1 envelope trimer.The Journal of biological chemistry · 2026Review
- Vaccine elicitation of HIV-1 neutralizing antibodies against both V2 apex and fusion peptide in rhesus macaques.Cell reports · 2026Article
- Multi-attribute monitoring (MAM) methodology for glycosylated subunit vaccines.Scientific reports · 2025Article
- Novel HIV-1 fusion peptide immunogens using glycan-engineered alphavirus-like particles.NPJ vaccines · 2025Article
- Vaccine Elicitation of HIV-1 Neutralizing Antibodies Against Both V2 Apex and Fusion Peptide in Rhesus Macaques.bioRxiv : the preprint server for biology · 2025Article
- Review
- Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation.Cell reports · 2024Article
- Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cholesterol reduction by immunization with a PCSK9 mimic.Cell reports · 2024Article
- Long trimer-immunization interval and appropriate adjuvant reduce immune responses to the soluble HIV-1-envelope trimer base.iScience · 2024Article
- Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide.Frontiers in immunology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors.
Adam S OliaVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Cheng ChengVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Tongqing ZhouVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Andrea BijuVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Darcy R HarrisVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Anita ChangelaVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Hongying DuanVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Vera B IvlevaVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Wing-Pui KongVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Li OuVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Reda RawiVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Yaroslav TsybovskyElectron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
David J Van WazerVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Angela R CorriganVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Christopher A GonelliVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Myungjin LeeVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Krisha McKeeVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Sandeep NarpalaVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Sijy O'DellVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Danealle K ParchmentVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Erik-Stephane D StancofskiVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Tyler StephensElectron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Ivy TanVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
I-Ting TengVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Shuishu WangVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Qing WeiDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Yongping YangVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Zhengrong YangDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Baoshan ZhangVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
VRC Production Program
Jan NovakDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Matthew B RenfrowDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Nicole A Doria-RoseVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Richard A KoupVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Adrian B McDermottVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Jason G GallVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Q Paula LeiVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
John R MascolaVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Peter D KwongVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
Funding
WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6MVaccine Immunology ProgramZIAAI005143 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KOUP, RICHARD A · 2019 to 2025
$51.8MDesign Of ImmunogensZIAAI005024 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ZHOU, TONGQING · 2009 to 2025
$21.5MHIV/AIDS Vaccine and Antibody DevelopmentZICAI005002 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHENG, CHENG · 2019 to 2025
$17.6MDesign of Antigenically-Specific Probes for Sera Analysis and MAb IsolationZICAI005111 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ZHOU, TONGQING · 2010 to 2025
$4.3MRational Immunogen Design Using Computational MethodsZICAI005114 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI RAWI, REDA · 2010 to 2025
$4.3MDefining the impact of glycan-microdomains of the HIV-1 Env glycan shieldR01AI162236 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NOVAK, JAN, RENFROW, MATTHEW B · 2021 to 2025
$3.6MNCI NIH HHS 75N91019D00024NIAID NIH HHS R01 AI162236
Abstract
Soluble HIV-1-envelope (Env) trimers elicit immune responses that target their solvent-exposed protein bases, the result of removing these trimers from their native membrane-bound context. To assess whether glycosylation could limit these base responses, we introduced sequons encoding potential
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.