Evidence map›Paper›PMID 37554445›Full record

ArticleiScience2023

Down syndrome is associated with altered frequency and functioning of tracheal multiciliated cells, and response to influenza virus infection.

Samantha N Thomas, Brian F Niemeyer, Rocio J Jimenez-Valdes, Alexander J Kaiser, Joaquin M Espinosa, Kelly D Sullivan, Andrew Goodspeed, James C Costello, Jonathan K Alder, Rodrigo Cañas-Arranz and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Samantha N ThomasDepartment of Bioengineering, University of Colorado Denver, Aurora, CO 80045, USA.
Brian F NiemeyerDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Rocio J Jimenez-ValdesDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Alexander J KaiserDepartment of Bioengineering, University of Colorado Denver, Aurora, CO 80045, USA.
Joaquin M EspinosaLinda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Kelly D SullivanLinda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Andrew GoodspeedDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
James C CostelloLinda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Jonathan K AlderDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Rodrigo Cañas-ArranzDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kambez H BenamDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6M
SARS-CoV adaptations through a Systems Biology Lens (SYBIL)U19AI135972 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Adolfo Garcia-Sastre · 2018 to 2026
$27.2M
Technology Development Project - Increasing the complexity of ex vivo human airway models for studying immune response to viral infectionU19AI142733 · NIAID · JACKSON LABORATORY · PI Damien Chaussabel · 2019 to 2026
$23.1M
Emulating Immune Dysregulation by Trisomy 21 in a Multi-Organ-on-a-Chip SystemR01HL159494 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HAJIPOURAN BENAM, KAMBEZ · 2021 to 2025
$3.6M
Understanding Down Syndrome as an InterferonopathyR01AI150305 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ESPINOSA, JOAQUIN M. · 2019 to 2020
$3.5M
A Microphysiological Mimicry of Human Lung-Bone Marrow Organ-Organ Crosstalk On-a-ChipU01EB029085 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HAJIPOURAN BENAM, KAMBEZ · 2019 to 2023
$2.0M
NCI NIH HHS P30 CA046934NHLBI NIH HHS R01 HL159494NIAID NIH HHS 75N93021C00014NIAID NIH HHS R01 AI150305NIAID NIH HHS U19 AI135972NIAID NIH HHS U19 AI142733NIBIB NIH HHS U01 EB029085
6 · The paper itself

Abstract

Individuals with Down syndrome (DS) clinically manifest severe respiratory illnesses; however, there is a paucity of data on how DS influences homeostatic physiology of lung airway, and its reactive responses to pulmonary pathogens. We generated well-differentiated ciliated airway epithelia using tracheas from wild-type and Dp(16)1/Yey mice

Indexed as

Biological sciencesCell biologyDisease

Identifiers

PMID37554445
PMCPMC10405068

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.