ArticleiScience2023
Polyethylene microplastics impede the innate immune response by disrupting the extracellular matrix and signaling transduction.
Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Serine protease HtrA promotesScience advances · 2026Article
- Article
- [Microplastic and skin-an update].Dermatologie (Heidelberg, Germany) · 2026Review
- Microplastics amplify the pro-inflammatory response to fungal mycelial fragments and spores in neutrophil-like cells.Frontiers in toxicology · 2026Article
- The Need to Implement Innovative Technologies to Advance Research on the Biotoxicity of Micro- and Nanoplastics.Environment & health (Washington, D.C.) · 2025Review
- Freeze-thaw cycles and biodegradable microplastics alter the microbial degradation of atrazine in mollisols.Eco-Environment & Health · 2025Article
- Superoxide Dismutase 3 Deficiency Disrupts the Regulation of Oxidative Stress Caused by Polystyrene Nanoplastics.Antioxidants (Basel, Switzerland) · 2025Article
- CD44 as a Central Integrator of Inflammation and Fibrosis: From Molecular Signaling to Environmental Modulation.International journal of molecular sciences · 2025Review
- Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review.Journal of exposure science & environmental epidemiology · 2025Article
- Role of microplastics in the tumor microenvironment (Review).Oncology letters · 2025Review
- Microplastics in the bloodstream can induce cerebral thrombosis by causing cell obstruction and lead to neurobehavioral abnormalities.Science advances · 2025Article
- A conceptual enzyme-cell therapy model to aid microplastic clearance from the vitreous humor.Frontiers in bioengineering and biotechnology · 2025Article
- The Emerging Threat of Micro- and Nanoplastics on the Maturation and Activity of Immune Cells.Biomolecules & therapeutics · 2025Review
- Microplastics: an often-overlooked issue in the transition from chronic inflammation to cancer.Journal of translational medicine · 2024Review
- Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions.World journal of gastroenterology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microplastics (MPs) can accumulate in animal organs. Numerous studies have linked MPs with immune system. However, the impact of MPs on immune response remains unclear. This study examined the innate immune response of mice exposed to 5 μm MPs. In the lipopolysaccharide challenge, mice treated with MPs exhibited lower levels of serum immune factors and activated immune cells. MPs disrupted immune-related receptors and cause dysfunction in cell signal transduction within the liver and spleen. Proteomic analysis revealed that MPs impede the activation of serum immune-related signals. In addition, the tissue section imaging exhibited a significant enrichment of MPs in the extracellular matrix (ECM), consistent with the ECM dysfunction and immune receptor suppression. Therefore, our data suggest excessive MPs accumulation in ECM inhibits cell signaling pathways, thereby suppressing the activation of immune responses. We propose the biotoxicity of MPs is partly through the MP disruption of ECM (MPDEM).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.