Evidence map›Paper›PMID 37554263›Full record

ArticleTheranostics2023

iNOS aggravates pressure overload-induced cardiac dysfunction via activation of the cytosolic-mtDNA-mediated cGAS-STING pathway.

Yongzheng Guo, Yuehua You, Fei-Fei Shang, Xiaowen Wang, Bi Huang, Boying Zhao, Dingyi Lv, Shenglan Yang, Ming Xie, Lingwen Kong and 4 more

Abstract read
In one paragraph

Article in Theranostics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

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  13. ESCRT-Mimetic Nanodegrader Targets STING for Anti-Inflammatory Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  14. Article
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  18. Mitochondrial DNA as a driver of inflammation via the cGAS-STING pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yongzheng GuoDivision of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Yuehua YouDivision of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Fei-Fei ShangInstitute of Life Science, Chongqing Medical University, Chongqing 400016, China.
Xiaowen WangDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Bi HuangDivision of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Boying ZhaoDepartment of Cardiothoracic Surgery, Chongqing University Central Hospital, Chongqing 400014, China.
Dingyi LvDivision of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Shenglan YangDivision of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Ming XieDepartment of Cardiothoracic Surgery, Chongqing University Central Hospital, Chongqing 400014, China.
Lingwen KongDepartment of Cardiothoracic Surgery, Chongqing University Central Hospital, Chongqing 400014, China.
Dingyuan DuDepartment of Cardiothoracic Surgery, Chongqing University Central Hospital, Chongqing 400014, China.
Suxin LuoDivision of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xin TianDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing 400016, China.
Yong XiaDivision of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA, MitochondrialHeart DiseasesNitric Oxide Synthase Type IIAnimalsCytosolHumansInflammationMiceMice, KnockoutMitochondriaMyocytes, CardiacNucleotidyltransferasesDNA, MitochondrialNitric Oxide Synthase Type IINos2 protein, mouseNucleotidyltransferasesCardiac dysfunctioncGASiNOSmtDNASterile inflammation

Identifiers

PMID37554263
PMCPMC10405855

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.