Evidence map›Paper›PMID 37554148›Full record

ArticleOpen medicine (Warsaw, Poland)2023

Analysis of heroin effects on calcium channels in rat cardiomyocytes based on transcriptomics and metabolomics.

Liping Su, Li Liu, Min Ji, Xiayun Hu, Min Liang, Ziyang Lu, Zhiguo Wang, Yaling Guan, Jinling Xiao, Mengjie Zhuang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open medicine (Warsaw, Poland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Liping SuDepartment of Pathology, First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, PR China.
Li LiuDepartment of Pathology, First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, PR China.
Min JiSchool of Basic Medicine, Xinjiang Medical University, Urumqi, Xinjiang, PR China.
Xiayun HuDepartment of Pathology, Shanghai Changhai Hospital, Shanghai, China.
Min LiangDiscipline Inspection and Supervision Department, First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, PR China.
Ziyang LuDepartment of Pathology, Qilu Hospital, Jinan, Shandong Province, PR China.
Zhiguo WangXinjiang Hengzheng Judicial Expertise Center, Urumqi, China.
Yaling GuanSchool of Basic Medicine, Xinjiang Medical University, Urumqi, Xinjiang, PR China.
Jinling XiaoSchool of Basic Medicine, Xinjiang Medical University, Urumqi, Xinjiang, PR China.
Mengjie ZhuangSchool of Basic Medicine, Xinjiang Medical University, Urumqi, Xinjiang, PR China.
Sensen ZhuSchool of Basic Medicine, Xinjiang Medical University, Urumqi, Xinjiang, PR China.
Long YangDepartment of Anesthesiology, First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, PR China.
Hongwei PuDepartment of Discipline Construction, First Affiliated Hospital, Xinjiang Medical University, No. 137, Liyushan South Road, Urumqi 830054, Xinjiang, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heroin can cause damage to many human organs, possibly leading to different types of arrhythmias and abnormal electrophysiological function of the heart muscle and the steady state of calcium-ion channels. We explored cardiomyocytes treated with heroin and the effect on calcium-ion channels. Transcriptomics and metabolomics were used to screen for differential genes and metabolite alterations after heroin administration to jointly analyze the effect of heroin on calcium channels in cardiomyocytes. Cardiomyocytes from primary neonatal rats were cultured

Indexed as

action potentialarrhythmiaheroinL-calcium channeltranscriptomics

Identifiers

PMID37554148
PMCPMC10404893

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.