ArticleAlcohol, clinical & experimental research2023
Influence of social rank on the development of long-term ethanol drinking trajectories in cynomolgus monkeys.
Article in Alcohol, clinical & experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 8 citations in OpenAlex.
- Sex-Specific Relationships Between Nociceptin/Orphanin FQ Peptide (NOP) Receptors and Alcohol Drinking: Longitudinal PET Studies in Cynomolgus Monkeys.Basic & clinical pharmacology & toxicology · 2026Article
- Individual differences in ethanol drinking meal structure are shaped by social environments.bioRxiv : the preprint server for biology · 2026Article
- Sex differences in compulsive alcohol drinking phenotypes: implications for decision-making and social behavior in a preclinical model.Psychopharmacology · 2026Article
- Patterns of chronic ethanol drinking in male and female cynomolgus monkeys.Alcohol, clinical & experimental research · 2026Article
- Ethanol self-administration reduced the efficacy of a behavioral intervention to decrease cocaine choice in socially housed male and female monkeys.Drug and alcohol dependence · 2025Article
- Punishment of ethanol choice in group-housed male cynomolgus monkeys.Drug and alcohol dependence · 2025Article
- Ethanol consumption prior to cocaine self-administration reduced vulnerability to cocaine reinforcement in socially subordinate female and male monkeys.Psychopharmacology · 2025Article
- Ethanol self-administration prior to cocaine self-administration reduces sensitivity to cocaine reinforcement in socially housed monkeys.The Journal of pharmacology and experimental therapeutics · 2025Article
- Imaging of Microtubules in a Nonhuman Primate Model of Alcohol Use Disorder.ACS pharmacology & translational science · 2025Article
- A role for the insula in establishing social dominance: structural and functional MRI studies in nonhuman primates.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Cognitive-Enhancing Effects of Acetylcholine Receptor Agonists in Group-Housed Cynomolgus Monkeys Who Drink Ethanol.The Journal of pharmacology and experimental therapeutics · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChronic stress contribute to the development of alcohol use disorder (AUD). However, characterizing the role of chronic social stressors in the development of problematic drinking trajectories in humans is complicated by practical and ethical constraints. Group-housed nonhuman primates develop social dominance hierarchies that represent a continuum of social experiences from enrichment in higher-ranked (dominant) monkeys to chronic social stress in lower-ranked (subordinate) individuals. This framework provides a translationally relevant model of chronic social stress that can be used to characterize its effects on vulnerability to AUD.
methodsTwelve male cynomolgus monkeys living in three social groups with established social dominance hierarchies were provided access to ethanol and water for 22 h/day, 4-5 days/week, for 1 year. Ethanol-free periods (2- or 3-day "weekends" or longer periods up to 10 days) were spent in social groups to maintain the stability of the social hierarchies. Observational studies conducted 6 months into the year of drinking assessed signs of ethanol withdrawal. After 1 year, monkeys were individually housed 24 h/day, 7 days/week for four consecutive weeks to examine the effect of eliminating the "weekends" spent socially housed.
resultsSubordinate monkeys had significantly higher mean daily ethanol intakes than dominant monkeys across 1 year of open access. Subordinates also had higher intakes on the first day back drinking following ethanol-free periods of 9-10 days. Moreover, during the last 4 weeks of open access, intakes on the first drinking day after an ethanol-free weekend increased significantly in subordinate monkeys. This effect diminished when all monkeys were individually housed for 4 weeks, indicating that the increased intake in subordinates was driven by the social environment.
conclusionsThese data demonstrate that social subordination, which is associated with chronic social stress, results in increased vulnerability to the development and maintenance of heavy drinking trajectories.
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