ArticleBioelectronic medicine2023
Obstructive sleep apnea improves with non-invasive hypoglossal nerve stimulation using temporal interference.
Article in Bioelectronic medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Hotspots and trends in acupuncture combined with non-invasive neuromodulation technology in the past 20 years: a bibliometric analysis.Frontiers in neurology · 2025Pooled it
- Advances in the application of temporal interference stimulation: a scoping review.Frontiers in human neuroscience · 2025Pooled it
- Personalized high-intensity temporal interference stimulation decouples cerebellar networks to enhance implicit learning.Journal of neuroengineering and rehabilitation · 2026Trial
- Non-Invasive Temporal Interference Electrical Stimulation Modulates Neurotransmitter Release and Improves Aberrant Neural Oscillations in Alzheimer's Disease.CNS neuroscience & therapeutics · 2026Article
- Temporal interference stimulation of peripheral nerves induces functionally diverse limb movements revealed by automated pose estimation and unsupervised behavioral analysis.Journal of neuroengineering and rehabilitation · 2025Article
- Miniaturized Wireless tDCS With Concentric Electrodes for Targeted Cortical Stimulation in Freely Moving Mice.Advanced healthcare materials · 2025Article
- Molecular Biomarkers and Therapeutic Approach of Patients with Diabetes and Obstructive Sleep Apnea.International journal of molecular sciences · 2025Review
- The same biophysical mechanism is involved in both temporal interference and direct kHz stimulation of peripheral nerves.Nature communications · 2025Article
- Non-invasive Modulation of Deep Brain Nuclei by Temporal Interference Stimulation.Neuroscience bulletin · 2025Article
- Focal control of non-invasive deep brain stimulation using multipolar temporal interference.Bioelectronic medicine · 2025Article
- Impact of neuromodulation on excessive daytime sleepiness: a narrative review.Frontiers in psychiatry · 2025Review
- Article
- Acoustic stimulation and other emerging approaches to enhance sleep: design notes for the next generation of closed-loop neurostimulation technology.Frontiers in neuroscience · 2025Review
- Quantitative analysis of noninvasive deep temporal interference stimulation: A simulation and experimental study.Heliyon · 2024Article
- Interfering with sleep apnea.Bioelectronic medicine · 2024Article
- Advanced neuroprosthetic electrode design optimized by electromagnetic finite element simulation: innovations and applications.Frontiers in bioengineering and biotechnology · 2024Review
- Article
- Transcranial Electrical Neurostimulation as a Potential Addiction Treatment.Inquiry : a journal of medical care organization, provision and financingReview
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13 authors.
Funding
Abstract
backgroundPeripheral nerve stimulation is used in both clinical and fundamental research for therapy and exploration. At present, non-invasive peripheral nerve stimulation still lacks the penetration depth to reach deep nerve targets and the stimulation focality to offer selectivity. It is therefore rarely employed as the primary selected nerve stimulation method. We have previously demonstrated that a new stimulation technique, temporal interference stimulation, can overcome depth and focality issues.
methodsHere, we implement a novel form of temporal interference, bilateral temporal interference stimulation, for bilateral hypoglossal nerve stimulation in rodents and humans. Pairs of electrodes are placed alongside both hypoglossal nerves to stimulate them synchronously and thus decrease the stimulation amplitude required to activate hypoglossal-nerve-controlled tongue movement.
resultsComparing bilateral temporal interference stimulation with unilateral temporal interference stimulation, we show that it can elicit the same behavioral and electrophysiological responses at a reduced stimulation amplitude. Traditional transcutaneous stimulation evokes no response with equivalent amplitudes of stimulation.
conclusionsDuring first-in-man studies, temporal interference stimulation was found to be well-tolerated, and to clinically reduce apnea-hypopnea events in a subgroup of female patients with obstructive sleep apnea. These results suggest a high clinical potential for the use of temporal interference in the treatment of obstructive sleep apnea and other diseases as a safe, effective, and patient-friendly approach.
trial registrationThe protocol was conducted with the agreement of the International Conference on Harmonisation Good Clinical Practice (ICH GCP), applicable United States Code of Federal Regulations (CFR) and followed the approved BRANY IRB File # 22-02-636-1279.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.