ArticleLipids in health and disease2023
LC/MS-based untargeted lipidomics reveals lipid signatures of nonpuerperal mastitis.
Article in Lipids in health and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Associations of obesity-related mammary intraductal secretions with inflammatory severity, immune dysregulation, and adverse prognosis in non-puerperal mastitis: a retrospective cohort study.Lipids in health and disease · 2025Article
- Energy Metabolism Dysregulation in Myocardial Infarction: An Integrative Analysis of Ischemic Cardiomyopathy.Current vascular pharmacology · 2025Article
- Plasma Lipidomics Reveals Lipid Signatures of Early Pregnancy in Mares.International journal of molecular sciences · 2024Article
- LC/MS-Based Untargeted Lipidomics Reveals Lipid Signatures of Sarcopenia.International journal of molecular sciences · 2024Article
- Prediction models for postoperative recurrence of non-lactating mastitis based on machine learning.BMC medical informatics and decision making · 2024Article
- Clinical Characteristics of Non-Puerperal Mastitis: A Retrospective Analysis of 724 Patients.International journal of women's health · 2024Article
- Novel insights: crosstalk with non-puerperal mastitis and immunity.Frontiers in immunology · 2024Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNonpuerperal mastitis (NPM) is a disease that presents with redness, swelling, heat, and pain during nonlactation and can often be confused with breast cancer. The etiology of NPM remains elusive; however, emerging clinical evidence suggests a potential involvement of lipid metabolism.
methodLiquid chromatography‒mass spectrometry (LC/MS)-based untargeted lipidomics analysis combined with multivariate statistics was performed to investigate the NPM lipid change in breast tissue. Twenty patients with NPM and 10 controls were enrolled in this study.
resultsThe results revealed significant differences in lipidomics profiles, and a total of 16 subclasses with 14,012 different lipids were identified in positive and negative ion modes. Among these lipids, triglycerides (TGs), phosphatidylethanolamines (PEs) and cardiolipins (CLs) were the top three lipid components between the NPM and control groups. Subsequently, a total of 35 lipids were subjected to screening as potential biomarkers, and the chosen lipid biomarkers exhibited enhanced discriminatory capability between the two groups. Furthermore, pathway analysis elucidated that the aforementioned alterations in lipids were primarily associated with the arachidonic acid metabolic pathway. The correlation between distinct lipid populations and clinical phenotypes was assessed through weighted gene coexpression network analysis (WGCNA).
conclusionsThis study demonstrates that untargeted lipidomics assays conducted on breast tissue samples from patients with NPM exhibit noteworthy alterations in lipidomes. The findings of this study highlight the substantial involvement of arachidonic acid metabolism in lipid metabolism within the context of NPM. Consequently, this study offers valuable insights that can contribute to a more comprehensive comprehension of NPM in subsequent investigations.
trial registrationShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (Number: 2019-702-57; Date: July 2019).
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