Evidence map›Paper›PMID 37553628›Full record

ArticleBMC cardiovascular disorders2023

Post-COVID-19 illness and associations with sex and gender.

Kenneth Mangion, Andrew J Morrow, Robert Sykes, Anna Kamdar, Catherine Bagot, George Bruce, Paul Connelly, Christian Delles, Vivienne B Gibson, Lynsey Gillespie and 9 more

Open access · goldAbstract read
In one paragraph

Article in BMC cardiovascular disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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  7. Establishment and characterization of an hFrontiers in immunology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 2 countries.

Kenneth MangionSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK. kenneth.mangion@glasgow.ac.uk.
Andrew J MorrowSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Robert SykesSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Anna KamdarSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Catherine BagotDepartment of Haemostasis and Thrombosis, Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde Health Board, Glasgow, UK.
George BruceDepartment of Medical Physics, NHS G Reater Glasgow and Clyde Health Board, Glasgow, UK.
Paul ConnellySchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Christian DellesSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Vivienne B GibsonDepartment of Haemostasis and Thrombosis, Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde Health Board, Glasgow, UK.
Lynsey GillespieProject Management Unit, Glasgow Clinical Research Facility, NHS Greater Glasgow and Clyde Health Board, Glasgow, UK.
Pauline Hall BarrientosDepartment of Medical Physics, NHS G Reater Glasgow and Clyde Health Board, Glasgow, UK.
Vera LennieDepartment of Cardiology, Aberdeen Royal Infirmary, Aberdeen, UK.
Giles RoditiDepartment of Radiology, NHS Greater Glasgow and Clyde Health Board, Glasgow, UK.
Naveed SattarSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
David StoboDepartment of Radiology, NHS Greater Glasgow and Clyde Health Board, Glasgow, UK.
Sarah Allwood-SpiersDepartment of Medical Physics, NHS G Reater Glasgow and Clyde Health Board, Glasgow, UK.
Alex McConnachieRobertson Centre for Biostatistics, School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Colin BerrySchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
CISCO-19 investigators
NHS Greater Glasgow and Clyde · GBQueen Elizabeth University Hospital · GBUniversity of Glasgow · GBCommittee on Climate Change · GBGlasgow Royal Infirmary · GBAberdeen Royal Infirmary · GBHeartFlow (United States) · USMRC University of Glasgow Centre for Virus Research · GBNational Institutes of Health · US

Funding

British Heart Foundation RE/18/6/34217Chief Scientist Office 311300
6 · The paper itself

Abstract

backgroundPost-COVID-19 syndromes have associated with female sex, but the pathophysiological basis is uncertain.

aimThere are sex differences in myocardial inflammation identified using cardiac magnetic resonance (CMR) in post-COVID-19 patients, and in patient reported health outcomes following COVID-19 infection.

designThis prospective study investigated the time-course of multiorgan injury in survivors of COVID-19 during convalescence.

methodsClinical information, blood biomarkers, and patient reported outcome measures were prospectively acquired at enrolment (visit 1) and 28-60 days post-discharge (visit 2). Chest computed tomography (CT) and CMR were performed at visit 2. Follow-up was carried out for serious adverse events, including death and rehospitalization.

resultsSixty-nine (43%) of 159 patients recruited were female. During the index admission, females had a lower peak C-reactive protein (74 mg/l (21,163) versus 123 mg/l (70, 192) p = 0.008) and peak ferritin (229 μg/l (103, 551) versus 514 μg/l (228, 1122) p < 0.001). Using the Modified Lake-Louise criteria, females were more likely to have definite evidence of myocardial inflammation (54% (37/68) versus 33% (30/90) p = 0.003). At enrolment and 28-60 days post-discharge, enhanced illness perception, higher levels of anxiety and depression and lower predicted maximal oxygen utilization occurred more commonly in women. The mean (SD, range) duration of follow-up after hospital discharge was 450 (88) days (range 290, 627 days). Compared to men, women had lower rates of cardiovascular hospitalization (0% versus 8% (7/90); p = 0.018).

conclusionsWomen demonstrated worse patient reported outcome measures at index admission and 28-60 days follow-up though cardiovascular hospitalization was lower.

Indexed as

COVID-19MyocarditisAftercareFemaleHumansInflammationMalePatient DischargeProspective StudiesSARS-CoV-2COVID-19Female sexMale sexMyocardial inflammationMyocarditisPost-COVID-19 syndromeSARS CoV-2Severe acute respiratory syndrome coronavirus-19

Identifiers

PMID37553628
PMCPMC10408208
OpenAlexW4385664735

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.