ArticleNature communications2023
Vitamin interdependencies predicted by metagenomics-informed network analyses and validated in microbial community microcosms.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
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- Keystone concept revisited: insights into microbial community dynamics and control.Nature reviews. Microbiology · 2026Review
- Piceatannol enhances antioxidant capacity and growth in weaned piglets by regulating of Nrf2-mediated redox homeostasis and modulating of the related gut microbiota.Journal of animal science and biotechnology · 2026Article
- A comprehensive ruminant microbial catalog (CRMC) reveals convergent selection for key vitamin-synthesizing pathways and genes across ruminants and human.GigaScience · 2026Article
- Ectomycorrhizal fungi recruit hyphae-associated bacteria that metabolize thiamine to promote pine symbiosis.The ISME journal · 2026Article
- Functional complementarity between vitamin B1 and B12 metabolisms shapes seasonal marine microbial communities.The ISME journal · 2026Article
- Metabolic blueprints of monocultures enable prediction and design of synthetic microbial consortia.bioRxiv : the preprint server for biology · 2026Article
- gcMeta 2025: a global repository of metagenome-assembled genomes enabling cross-ecosystem microbial discovery and function research.Nucleic acids research · 2026Article
- Common and recurrent dysregulated molecular network of placental hypoxia and associated vasculogenesis and angiogenesis in fetal growth restriction.Frontiers in endocrinology · 2026Article
- Potentiators empower synthetic microbiomes as silent guardians against co-contamination.Nature communications · 2025Article
- Microbial model communities exhibit widespread metabolic interdependencies.Communications biology · 2025Article
- microbetag: simplifying microbial network interpretation through annotation, enrichment tests, and metabolic complementarity analysis.Genome biology · 2025Article
- Cobamide-based interactions between soil bacteria can be predicted based on monoculture growth.bioRxiv : the preprint server for biology · 2025Article
- Harmful algal bloom speciesmBio · 2025Article
- Vitamin biosynthesis in the gut: interplay between mammalian host and its resident microbiota.Microbiology and molecular biology reviews : MMBR · 2025Review
- Maize associated bacterial and fungal microbiomes show contrasting conformation patterns dependent on plant compartment and water availability.BMC plant biology · 2025Article
- Model cyanobacterial consortia reveal a consistent core microbiome independent of inoculation source or cyanobacterial host species.The ISME journal · 2025Article
- Discovery and cultivation of prokaryotic taxa in the age of metagenomics and artificial intelligence.The ISME journal · 2025Article
- Influences of fluctuating nutrient loadings on nitrate-reducing microorganisms in rivers.ISME communications · 2025Article
- Dark ocean archaeal and bacterial chemoautotrophs drive vitamin B1 production in oxygen minimum zones.ISME communications · 2025Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metagenomic or metabarcoding data are often used to predict microbial interactions in complex communities, but these predictions are rarely explored experimentally. Here, we use an organism abundance correlation network to investigate factors that control community organization in mine tailings-derived laboratory microbial consortia grown under dozens of conditions. The network is overlaid with metagenomic information about functional capacities to generate testable hypotheses. We develop a metric to predict the importance of each node within its local network environments relative to correlated vitamin auxotrophs, and predict that a Variovorax species is a hub as an important source of thiamine. Quantification of thiamine during the growth of Variovorax in minimal media show high levels of thiamine production, up to 100 mg/L. A few of the correlated thiamine auxotrophs are predicted to produce pantothenate, which we show is required for growth of Variovorax, supporting that a subset of vitamin-dependent interactions are mutualistic. A Cryptococcus yeast produces the B-vitamin pantothenate, and co-culturing with Variovorax leads to a 90-130-fold fitness increase for both organisms. Our study demonstrates the predictive power of metagenome-informed, microbial consortia-based network analyses for identifying microbial interactions that underpin the structure and functioning of microbial communities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.