Evidence map›Paper›PMID 37553240›Full record

ArticleeNeuro2023

Somatostatin-Expressing Neurons in the Ventral Tegmental Area Innervate Specific Forebrain Regions and Are Involved in Stress Response.

Elina Nagaeva, Annika Schäfer, Anni-Maija Linden, Lauri V Elsilä, Ksenia Egorova, Juzoh Umemori, Maria Ryazantseva, Esa R Korpi

Open access · goldAbstract read
In one paragraph

Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Growth AxisGenes · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Elina NagaevaDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland elina.nagaeva@helsinki.fi esa.korpi@helsinki.fi.ORCID 0000-0003-2828-6234
Annika SchäferDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Anni-Maija LindenDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Lauri V ElsiläDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-9744-4753
Ksenia EgorovaDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Juzoh UmemoriGene and Cell Technology, A. I. Virtanen Institute for Molecular Science, University of Eastern Finland, 70210 Kuopio, Finland.
Maria RyazantsevaHiLIFE Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland.
Esa R KorpiDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0003-0683-4009
University of Helsinki · FIUniversity of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Expanding knowledge about the cellular composition of subcortical brain regions demonstrates large heterogeneity and differences from the cortical architecture. Previously we described three subtypes of somatostatin-expressing (Sst) neurons in the mouse ventral tegmental area (VTA) and showed their local inhibitory action on the neighboring dopaminergic neurons (Nagaeva et al., 2020). Here, we report that Sst+ neurons especially from the anterolateral part of the mouse VTA also project far outside the VTA and innervate forebrain regions that are mainly involved in the regulation of emotional behavior, including the ventral pallidum, lateral hypothalamus, the medial part of the central amygdala, anterolateral division of the bed nucleus of stria terminalis, and paraventricular thalamic nucleus. Deletion of these VTA

Indexed as

Dopaminergic NeuronsVentral Tegmental AreaAnimalsEfferent PathwaysHypothalamic Area, LateralMiceSomatostatinSomatostatinbehavioral phenotypesmidbrainopioid sensitizationsomatostatin neuronsstress reactionsVTA projection neurons

Identifiers

PMID37553240
PMCPMC10464661
OpenAlexW4385655471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.