Evidence map›Paper›PMID 37553180›Full record

ArticleLearning & memory (Cold Spring Harbor, N.Y.)2023

Measuring human context fear conditioning and retention after consolidation.

Yanfang Xia, Jelena Wehrli, Samuel Gerster, Marijn Kroes, Maxime Houtekamer, Dominik R Bach

Open access · diamondAbstract read
In one paragraph

Article in Learning & memory (Cold Spring Harbor, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Yanfang XiaComputational Psychiatry Research, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, 8032 Zurich, Switzerland.ORCID 0000-0002-9885-1748
Jelena WehrliComputational Psychiatry Research, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, 8032 Zurich, Switzerland.ORCID 0000-0001-9761-3775
Samuel GersterComputational Psychiatry Research, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, 8032 Zurich, Switzerland.ORCID 0000-0001-6507-739X
Marijn KroesDonders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen 6525 GA, the Netherlands.ORCID 0000-0002-5329-9566
Maxime HoutekamerDonders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen 6525 GA, the Netherlands.ORCID 0000-0003-3364-8551
Dominik R BachComputational Psychiatry Research, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, 8032 Zurich, Switzerland d.bach@uni-bonn.de.ORCID 0000-0003-3717-2036
University of Zurich · CHRadboud University Nijmegen · NLWellcome Centre for Human Neuroimaging · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Fear conditioning is a laboratory paradigm commonly used to investigate aversive learning and memory. In context fear conditioning, a configuration of elemental cues (conditioned stimulus [CTX]) predicts an aversive event (unconditioned stimulus [US]). To quantify context fear acquisition in humans, previous work has used startle eyeblink responses (SEBRs), skin conductance responses (SCRs), and verbal reports, but different quantification methods have rarely been compared. Moreover, preclinical intervention studies mandate recall tests several days after acquisition, and it is unclear how to induce and measure context fear memory retention over such a time interval. First, we used a semi-immersive virtual reality paradigm. In two experiments (

Indexed as

Conditioning, ClassicalFearAvoidance LearningCuesHumansMemory

Identifiers

PMID37553180
PMCPMC10519410
OpenAlexW4385668315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.