ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2023
Prevalence and predictors of primary nonadherence to medications prescribed in primary care.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Diabetes Medication Regimen Complexity and Glycemic Outcomes among Medically Underserved Latino Adults: Implications for Pharmacoequity.Journal of immigrant and minority health · 2026Article
- Development and Validation of Digital Decision Aids to Support Medication Adherence in Older Adults: A Scoping Review.Pharmacy (Basel, Switzerland) · 2026Review
- Real-World Upadacitinib Persistence and Clinical Outcomes Among Canadian Patients with Inflammatory Arthritis from a Patient Support Program: The UPRAISE Study.Rheumatology and therapy · 2026Article
- New and persistent psychoactive medication use in intensive care unit survivors with COVID-19: a multicentre population-based cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Article
- Artificial intelligence approaches to predicting treatment non-adherence in chronic diseases: a narrative review.Frontiers in digital health · 2026Review
- Therapy gaps for patients with heart failure and reduced kidney function: A prospective cohort study.ESC heart failure · 2025Observational
- Hyperkalemia and maintenance of renin-angiotensin system inhibitor therapy after initiating SGLT-2 or DPP-4 inhibitors.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- University Pharmacy Clinic: Preventing Errors and Enhancing Lives Through Expert Medication Management.Pharmacy (Basel, Switzerland) · 2025Article
- Article
- Medication nonadherence - definition, measurement, prevalence, and causes: reflecting on the past 20 years and looking forwards.Frontiers in pharmacology · 2025Review
- Influence of patient characteristics onJGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Social Support and Adherence to Treatment Regimens among Patients Undergoing Hemodialysis.Healthcare (Basel, Switzerland) · 2024Article
- Prescription Trends of Thiazide Diuretics in a Canadian Primary Care Population From 2015 to 2021.CJC open · 2024Article
- Exploring Patient Beliefs and Medication Adherence in the Mediterranean Context: A Cross-Sectional Study in Patients with Cardiovascular Diseases and Cardiometabolic Disorders in Greece-The IACT-Study.Life (Basel, Switzerland) · 2023Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMost research on medication adherence has focused on secondary nonadherence and persistence to therapy. Medication prescriptions that are never filled by patients (primary nonadherence) remain understudied in the general population.
methodsWe linked prescribing data from primary care electronic medical records to comprehensive pharmacy dispensing claims between January 2013 and April 2019 in British Columbia (BC) to estimate primary nonadherence, defined as failure to dispense a new medication or its equivalent within 6 months of the prescription date. We used hierarchical multivariable logistic regression to determine prescriber, patient and medication factors associated with primary nonadherence among community-dwelling patients in primary care.
resultsAmong 150 565 new prescriptions to 34 243 patients, 17% of prescriptions were never filled. Primary nonadherence was highest for drugs prescribed mostly on an as-needed basis, including topical corticosteroids (35.1%) and antihistamines (23.4%). In multivariable analysis, primary nonadherence was lower for prescriptions issued by male prescribers (odds ratio [OR] 0.66, 95% confidence interval [CI] 0.50-0.88). Primary nonadherence decreased with patient age (OR 0.91, 95% CI 0.90-0.92 for each additional 10 years) but increased with polypharmacy among patients aged 65 years or older. Patients filled more than 82% of their medication prescriptions within 2 weeks after their primary care provider visit.
interpretationThe prevalence of primary nonadherence to new prescriptions was 17%. Interventions to address primary nonadherence could target older patients with multiple medication use and within the first 2 weeks of the prescription issue date.
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