Evidence map›Paper›PMID 37552984›Full record

ArticleCurrent biology : CB2023

An RFX transcription factor regulates ciliogenesis in the closest living relatives of animals.

Maxwell C Coyle, Adia M Tajima, Fredrick Leon, Semil P Choksi, Ally Yang, Sarah Espinoza, Timothy R Hughes, Jeremy F Reiter, David S Booth, Nicole King

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Cilia and transcription: a mini review.Frontiers in cell and developmental biology · 2025
    Review
  13. Article
  14. Cell differentiation controls iron assimilation in a choanoflagellate.bioRxiv : the preprint server for biology · 2024
    Article
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Maxwell C CoyleHoward Hughes Medical Institute and Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA.
Adia M TajimaHoward Hughes Medical Institute and Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA.
Fredrick LeonDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Semil P ChoksiDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Ally YangDonnelly Centre for Cellular and Biomolecular Research, Toronto, M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, M5S 3E1, Canada.
Sarah EspinozaHoward Hughes Medical Institute and Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA.
Timothy R HughesDonnelly Centre for Cellular and Biomolecular Research, Toronto, M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, M5S 3E1, Canada.
Jeremy F ReiterDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
David S BoothDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Nicole KingHoward Hughes Medical Institute and Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA. Electronic address: nking@berkeley.edu.
Howard Hughes Medical Institute · USUniversity of California, San Francisco · USUniversity of Toronto · CA

Funding

THE MOLECULAR BASIS OF CELL FUNCTIONT32GM007232 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BILDER, DAVID, UNAL, ELCIN · 1985 to 2022
$36.4M
Hedgehog signaling at the cell's antenna: Smoothened and the primary ciliumR01AR054396 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeremy F Reiter · 2007 to 2026
$9.0M
Transition zone control of ciliary signalingR01DE029454 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REITER, JEREMY F · 2019 to 2022
$2.3M
Howard Hughes Medical InstituteNIAMS NIH HHS R01 AR054396NIDCR NIH HHS R01 DE029454NIGMS NIH HHS T32 GM007232
6 · The paper itself

Abstract

Cilia allowed our protistan ancestors to sense and explore their environment, avoid predation, and capture bacterial prey.

Indexed as

DNA-Binding ProteinsTranscription FactorsAnimalsCiliaForkhead Transcription FactorsGene Expression RegulationPromoter Regions, GeneticRegulatory Factor X Transcription FactorsDNA-Binding ProteinsForkhead Transcription FactorsRegulatory Factor X Transcription FactorsTranscription Factorsanimal originschoanoflagellateciliaciliogenesisevolutionFoxJ1RFXtranscription factor

Identifiers

PMID37552984
PMCPMC10530576
OpenAlexW4385638126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.