Evidence map›Paper›PMID 37552973›Full record

ArticleObesity facts2023

How Could Different Obesity Scenarios Alter the Burden of Type 2 Diabetes and Liver Disease in Saudi Arabia?

Timothy Coker, Jennifer Saxton, Lise Retat, John Guzek, Joshua Card-Gowers, Nasser F BinDhim, Nora A Althumiri, Khalid Aldubayan, Habeeb I A Razack, Laura Webber and 1 more

Open access · goldAbstract read
In one paragraph

Article in Obesity facts, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Timothy CokerHealthLumen, London, UK.
Jennifer SaxtonHealthLumen, London, UK.
Lise RetatHealthLumen, London, UK.
John GuzekHealthLumen, London, UK.
Joshua Card-GowersHealthLumen, London, UK.
Nasser F BinDhimSharik Association for Health Research, Riyadh, Saudi Arabia.
Nora A AlthumiriSharik Association for Health Research, Riyadh, Saudi Arabia.
Khalid AldubayanDepartment of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Habeeb I A RazackCollege of Medicine, King Saud University, Riyadh, Saudi Arabia.
Laura WebberHealthLumen, London, UK.
Saleh A AlqahtaniLiver Transplant Centre, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
King Saud University · SAAlfaisal University · SAKing Faisal Specialist Hospital & Research Centre · SASaudi Heart Association · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionObesity is a major risk factor for type 2 diabetes (T2DM) and liver disease, and obesity-attributable liver disease is a common indication for liver transplant. Obesity prevalence in Saudi Arabia (SA) has increased in recent decades. SA has committed to the WHO "halt obesity" target to shift prevalence to 2010 levels by 2025. We estimated the future benefits of reducing obesity in SA on incidence and costs of T2DM and liver disease under two policy scenarios: (1) SA meets the "halt obesity" target; (2) population body mass index (BMI) is reduced by 1% annually from 2020 to 2040.

methodsWe developed a dynamic microsimulation of working-age people (20-59 years) in SA between 2010 and 2040. Model inputs included population demographic, disease and healthcare cost data, and relative risks of diseases associated with obesity. In our two policy scenarios, we manipulated population BMI and compared predicted disease incidence and associated healthcare costs to a baseline "no change" scenario.

resultsAdults <35 years are expected to meet the "halt obesity" target, but those ≥35 years are not. Obesity is set to decline for females, but to increase amongst males 35-59 years. If SA's working-age population achieved either scenario, >1.15 million combined cases of T2DM, liver disease, and liver cancer could be avoided by 2040. Healthcare cost savings for the "halt obesity" and 1% reduction scenarios are 46.7 and 32.8 billion USD, respectively.

conclusionSA's younger working-age population is set to meet the "halt obesity" target, but those aged 35-59 are off track. Even a modest annual 1% BMI reduction could result in substantial future health and economic benefits. Our findings strongly support universal initiatives to reduce population-level obesity, with targeted initiatives for working-age people ≥35 years of age.

Indexed as

Diabetes Mellitus, Type 2Liver DiseasesAdultFemaleHumansMaleObesityRisk FactorsSaudi ArabiaDynamic microsimulation modellingLiver cancerLiver diseaseNon-communicable diseasesObesityType 2 diabetes

Identifiers

PMID37552973
PMCPMC10697749
OpenAlexW4385651274

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.