ArticleEnvironmental science & technology2023
Effects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study.
Article in Environmental science & technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Associations between extreme temperatures and hospitalizations among Chinese cancer patients with atrial fibrillation: a case-crossover study.Cardio-oncology (London, England) · 2026Article
- Associations of 6600 SomaScan proteins with demographic, lifestyle, environmental and health characteristics in Chinese adults.Scientific reports · 2026Article
- Associations of daily air temperature with lung function and biomarkers of inflammation and oxidative stress in chronic obstructive pulmonary disease.Annals of the American Thoracic Society · 2026Article
- Burden of Non-communicable Diseases Attributable to High and Low Ambient Temperatures, 1990-2031: A Forecasting Analysis for GBD 2021.Current medical science · 2026Article
- Ambient temperature exposure on inflammatory blood proteins-A longitudinal self-sampling survey in young Swedish adults.iScience · 2026Article
- Acute Impact of Nonoptimal Ambient Temperatures on Plasma Levels of 3000 Proteins in Chinese Adults.Environmental science & technology · 2025Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence has revealed that exposure to low temperatures is linked to a higher risk of chronic diseases and death; however, the mechanisms underlying the observed associations are still poorly understood. We performed a cross-sectional analysis with 1115 participants from the population-based KORA F4 study, which was conducted in Augsburg, Germany, from 2006 to 2008. Seventy-one inflammation-related protein biomarkers were analyzed in serum using proximity extension assay technology. We employed generalized additive models to explore short- and medium-term effects of air temperature on biomarkers of subclinical inflammation at cumulative lags of 0-1 days, 2-6 days, 0-13 days, 0-27 days, and 0-55 days. We found that short- and medium-term exposures to lower air temperature were associated with higher levels in 64 biomarkers of subclinical inflammation, such as Protein S100-A12 (EN-RAGE), Interleukin-6 (IL-6), Interleukin-10 (IL-10), C-C motif chemokine 28 (CCL28), and Neurotrophin-3 (NT-3). More pronounced associations between lower air temperature and higher biomarker of subclinical inflammation were observed among older participants, people with cardiovascular disease or prediabetes/diabetes, and people exposed to higher levels of air pollution (PM
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