Evidence map›Paper›PMID 37552821›Full record

ArticleAmerican journal of respiratory cell and molecular biology2023

Eosinophil Phenotypes Are Functionally Regulated by Resolvin D2 during Allergic Lung Inflammation.

Thayse R Brüggemann, Hong Yong Peh, Luciana P Tavares, Julie Nijmeh, Ashley E Shay, Rafael M Rezende, Toby B Lanser, Charles N Serhan, Bruce D Levy

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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  10. Back to the Eosinophil: Resolvin Spatiotemporal Regulation.American journal of respiratory cell and molecular biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Thayse R BrüggemannPulmonary and Critical Care Medicine, Department of Internal Medicine.
Hong Yong PehPulmonary and Critical Care Medicine, Department of Internal Medicine.
Luciana P TavaresPulmonary and Critical Care Medicine, Department of Internal Medicine.
Julie NijmehPulmonary and Critical Care Medicine, Department of Internal Medicine.
Ashley E ShayCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, and.
Rafael M RezendeAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Toby B LanserAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Charles N SerhanCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, and.
Bruce D LevyPulmonary and Critical Care Medicine, Department of Internal Medicine.ORCID 0000-0001-9515-5731
Pulmonary and Critical Care Associates · USBrigham and Women's Hospital · US

Funding

Resolution Mechanisms in Acute Inflammation: Resolution PharmacologyP01GM095467 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2011 to 2020
$14.8M
Specialized Pro-Resolving Mediators in AsthmaR01HL122531 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEVY, BRUCE D · 2014 to 2024
$4.7M
Evaluating Resolution Mechanisms for Infectious InflammationR35GM139430 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2021 to 2025
$3.6M
NHLBI NIH HHS R01 HL122531NIGMS NIH HHS P01 GM095467NIGMS NIH HHS R35 GM139430NIH HHS P01GM0955467NIH HHS R01HL122531NIH HHS R35GM139430
6 · The paper itself

Abstract

Eosinophils (Eos) reside in multiple organs during homeostasis and respond rapidly to an inflammatory challenge. Although Eos share chemical staining properties, they also demonstrate phenotypic and functional plasticity that is not fully understood. Here, we used a murine model of allergic lung inflammation to characterize Eos subsets and determine their spatiotemporal and functional regulation during inflammation and its resolution in response to resolvin D2 (RvD2), a potent specialized proresolving mediator. Two Eos subsets were identified by CD101 expression with distinct anatomic localization and transcriptional signatures at baseline and during inflammation. CD101

Indexed as

Alveolitis, Extrinsic AllergicPneumoniaPulmonary EosinophiliaAnimalsBronchoalveolar Lavage FluidDocosahexaenoic AcidsEosinophilsInflammationMicePhenotypeDocosahexaenoic Acidsresolvin D2allergic inflammationeosinophilsresolvin D2specialized proresolving mediators

Identifiers

PMID37552821
PMCPMC10704125
OpenAlexW4385650860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.