Evidence map›Paper›PMID 37552766›Full record

ArticleBiochemistry2023

Structure-Guided Discovery of N

Kafi K J Belfon, Nandini Sharma, Rachael Zigweid, Madison Bolejack, Doug Davies, Thomas E Edwards, Peter J Myler, Jarrod B French

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kafi K J BelfonDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794, United States.ORCID 0009-0003-9588-4290
Nandini SharmaThe Hormel Institute, University of Minnesota, Austin, Minnesota 55912, United States.
Rachael ZigweidSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.
Madison BolejackSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.
Doug DaviesSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.
Thomas E EdwardsSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.
Peter J MylerSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.
Jarrod B FrenchThe Hormel Institute, University of Minnesota, Austin, Minnesota 55912, United States.ORCID 0000-0002-6762-1309
Center for Infectious Disease Research · USUniversity of Minnesota · USStony Brook University · US

Funding

Centers for Research on Structural Biology of Infectious Diseases: Universal Influenza Vaccine Research75N93022C00036 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI STAKER, BART · 2022 to 2025
$21.7M
Mechanisms that govern assembly and function of higher order protein structures of purine metabolic enzymesR35GM124898 · NIGMS · UNIVERSITY OF MINNESOTA · PI FRENCH, JARROD B · 2017 to 2021
$2.2M
NIAID NIH HHS 75N93022C00036NIAID NIH HHS HHSN272200700057CNIAID NIH HHS HHSN272201200025CNIAID NIH HHS HHSN272201700059CNIGMS NIH HHS R35 GM124898
6 · The paper itself

Abstract

Because purine nucleotides are essential for all life, differences between how microbes and humans metabolize purines can be exploited for the development of antimicrobial therapies. While humans biosynthesize purine nucleotides in a 10-step pathway, most microbes utilize an additional 11th enzymatic activity. The human enzyme, aminoimidazole ribonucleotide (AIR) carboxylase generates the product 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) directly. Most microbes, however, require two separate enzymes, a synthetase (PurK) and a mutase (PurE), and proceed through the intermediate, N

Indexed as

Intramolecular TransferasesRibonucleotidesEscherichia coliHumansPurine NucleotidesIntramolecular TransferasesN(5)-carboxyaminoimidazole ribonucletide mutasePurine NucleotidesRibonucleotides

Identifiers

PMID37552766
PMCPMC10484210
OpenAlexW4385655661

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.