ArticleProceedings of the National Academy of Sciences of the United States of America2023
The genomic landscape of swine influenza A viruses in Southeast Asia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Molecular Epidemiology and Evolution of Swine Influenza A Viruses, Vietnam, 2020-2024.Emerging infectious diseases · 2026Article
- Genetic Characteristics and Pathogenicity of Recent G4 Eurasian Avian-like H1N1 Swine Influenza Viruses in China.Veterinary sciences · 2026Article
- Characterizing the Epidemiology of Influenza A Viruses at the Swine-Human Interface: Study Protocol of the PigFluCam+ Project in Cambodia.JMIR research protocols · 2026Article
- Multiplex serological profiling reveals diverse avian and mammalian influenza A virus exposure in swine.iScience · 2026Article
- Epidemiology and Risk Modelling of Influenza A Virus Within and Between Pig Herds in Northern Lao PDR.Transboundary and emerging diseases · 2026Article
- Genetic Characterization of Swine Influenza Viruses in Thailand in 2019-2025 Reveals Novel Reassortants.Transboundary and emerging diseases · 2026Article
- Transmission Dynamics of Torque Teno Sus Virus 1 (TTSuV1) Between Wild and Farmed Pigs: A Molecular Tool for Monitoring Cross-Population Spillover in Swine.Microorganisms · 2025Article
- Continuous evolution of Eurasian avian-like H1N1 swine influenza viruses with pdm/09-derived internal genes enhances pathogenicity in mice.Journal of virology · 2025Article
- Article
- The global burden of swine influenza and its mitigation.Open veterinary journal · 2025Review
- Genetic and molecular characterization of a novel reassortant H3N2 influenza virus from a sick pig in Eastern China in 2019.Veterinary research · 2025Article
- WaveSeekerNet: accurate prediction of influenza A virus subtypes and host source using attention-based deep learning.GigaScience · 2025Article
- Transmission of Swine Influenza A Viruses along Pig Value Chains, Cambodia, 2020-2022.Emerging infectious diseases · 2024Article
- Reverse zoonosis of the 2022-2023 human seasonal H3N2 detected in swine.Npj viruses · 2024Article
- Avian Influenza Virus A(H5Nx) and Prepandemic Candidate Vaccines: State of the Art.International journal of molecular sciences · 2024Review
- Ingrained: Rice farming and the risk of zoonotic spillover, examples from Cambodia.One health (Amsterdam, Netherlands) · 2024Review
- Phylodynamic and Evolution of the Hemagglutinin (HA) and Neuraminidase (NA) Genes of Influenza A(H1N1) pdm09 Viruses Circulating in the 2009 and 2023 Seasons in Italy.Pathogens (Basel, Switzerland) · 2024Article
- Influenza A Virus Utilizes the Nasolacrimal System to Establish Respiratory Infection after Ocular Exposure in the Swine Model.Transboundary and emerging diseases · 2024Article
- Existing Evidence for Influenza B Virus Adaptations to Drive Replication in Humans as the Primary Host.Viruses · 2023Review
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Authors and funding
17 authors.
Funding
Abstract
Swine are a primary source for the emergence of pandemic influenza A viruses. The intensification of swine production, along with global trade, has amplified the transmission and zoonotic risk of swine influenza A virus (swIAV). Effective surveillance is essential to uncover emerging virus strains; however gaps remain in our understanding of the swIAV genomic landscape in Southeast Asia. More than 4,000 nasal swabs were collected from pigs in Cambodia, yielding 72 IAV-positive samples by RT-qPCR and 45 genomic sequences. We unmasked the cocirculation of multiple lineages of genetically diverse swIAV of pandemic concern. Genomic analyses revealed a novel European avian-like H1N2 swIAV reassortant variant with North American triple reassortant internal genes, that emerged approximately seven years before its first detection in pigs in 2021. Using phylogeographic reconstruction, we identified south central China as the dominant source of swine viruses disseminated to other regions in China and Southeast Asia. We also identified nine distinct swIAV lineages in Cambodia, which diverged from their closest ancestors between two and 15 B.P., indicating significant undetected diversity in the region, including reverse zoonoses of human H1N1/2009 pandemic and H3N2 viruses. A similar period of cryptic circulation of swIAVs occurred in the decades before the H1N1/2009 pandemic. The hidden diversity of swIAV observed here further emphasizes the complex underlying evolutionary processes present in this region, reinforcing the importance of genomic surveillance at the human-swine interface for early warning of disease emergence to avoid future pandemics.
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