Evidence map›Paper›PMID 37552655›Full record

ArticleNano letters2023

Anapole-Assisted Low-Power Optical Trapping of Nanoscale Extracellular Vesicles and Particles.

Ikjun Hong, Chuchuan Hong, Oleg S Tutanov, Clark Massick, Mark Castleberry, Qin Zhang, Dennis K Jeppesen, James N Higginbotham, Jeffrey L Franklin, Kasey Vickers and 2 more

Abstract read
In one paragraph

Article in Nano letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ikjun HongVanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0003-1275-7740
Chuchuan HongVanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-1329-9385
Oleg S TutanovDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Clark MassickDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.ORCID 0009-0009-4418-2006
Mark CastleberryDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Qin ZhangDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Dennis K JeppesenDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.ORCID 0000-0002-7480-8083
James N HigginbothamDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Jeffrey L FranklinDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Kasey VickersDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Robert J CoffeyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Justus C NdukaifeVanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-8524-0657

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Non-coding RNA & Bioinformatics CoreP01HL116263 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAVIES, SEAN STEPHEN · 2014 to 2025
$24.7M
Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal CancerP50CA236733 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STEPHEN W. FESIK · 2019 to 2026
$19.6M
Roles for Supermeres in CRC ProgressionP01CA229123 · NCI · VANDERBILT UNIVERSITY · PI Alissa M Weaver · 2020 to 2026
$12.9M
Integrated approach to study early and late events in colonic neoplasia: mouse to manR35CA197570 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2017 to 2026
$9.4M
Uncovering exRNA and protein determinants of secreted vesicle heterogeneity by flow cytometric purification of vesicle subsets from cells and plasmaUH3CA241685 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHAREST, ALAIN, COFFEY, ROBERT J. · 2021 to 2022
$2.1M
American Heart Association-American Stroke Association 971070NCI NIH HHS P01 CA229123NCI NIH HHS P50 CA236733NCI NIH HHS R35 CA197570NCI NIH HHS UH3 CA241685NHLBI NIH HHS P01 HL116263NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

This study addresses the challenge of trapping nanoscale biological particles using optical tweezers without the photothermal heating effect and the limitation presented by the diffraction limit. Optical tweezers are effective for trapping microscopic biological objects but not for nanoscale specimens due to the diffraction limit. To overcome this, we present an approach that uses optical anapole states in all-dielectric nanoantenna systems on distributed Bragg reflector substrates to generate strong optical gradient force and potential on nanoscale biological objects with negligible temperature rise below 1 K. The anapole antenna condenses the accessible electromagnetic energy to scales as small as 30 nm. Using this approach, we successfully trapped nanosized extracellular vesicles and supermeres (approximately 25 nm in size) using low laser power of only 10.8 mW. This nanoscale optical trapping platform has great potential for single molecule analysis while precluding photothermal degradation.

Indexed as

Anapoledistributed Bragg reflectorelectric field enhancementextracellular vesiclesnanotweezersupermeres

Identifiers

PMID37552655
PMCPMC10652798

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.