Trial reportAmerican journal of respiratory and critical care medicine2023
Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial.
Abstract readRandomized Controlled TrialMulticenter Study
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Conservative Oxygen Targets in Mechanically Ventilated Patients (OXY-BREATHES): A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Critical care medicine · 2026Pooled it
- Conservative versus liberal oxygen therapy for mechanically ventilated patients: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- Conservative versus liberal oxygen therapy in mechanically ventilated patients: A systematic review with meta-analysis.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2025Pooled it
- Lower or higher oxygenation targets in the intensive care unit: an individual patient data meta-analysis.Intensive care medicine · 2024Pooled it
- Impact of Oxygen Targets on Sepsis Outcome: A Randomized Controlled Trial.Shock (Augusta, Ga.) · 2026Trial
- Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial.Intensive care medicine · 2026Trial
- Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial.JAMA · 2025Trial
- Long-term mortality and health-related quality of life with lower versus higher oxygenation targets in intensive care unit patients with COVID-19 and severe hypoxaemia.Intensive care medicine · 2024Trial
- Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial.American journal of respiratory and critical care medicine · 2023Trial
- Balancing lung and brain: physiological strategies for ARDS management in acute brain injury.Intensive care medicine · 2026Review
- The Acute Respiratory Distress Syndrome (ARDS): epidemiology, etiology, molecular mechanisms, diagnosis and therapeutic strategies.Molecular biomedicine · 2026Review
- Optimal oxygenation in the intensive care unit: what recent trials do-and do not-tell us.Acute and critical care · 2026Article
- Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026.Intensive care medicine · 2026Article
- Precision Oxygen Therapy in the Intensive Care Unit: Matching Oxygen Exposure to Patient Phenotypes.Journal of personalized medicine · 2026Article
- Partial pressure of oxygen, hyperoxemia and hyperoxia in the intensive care or anesthesia setting.Medical gas research · 2026Review
- Temporal dimensions of oxygen saturation exposure and clinical outcomes in critically ill patients: a retrospective multi-database cohort study.Critical care (London, England) · 2025Article
- Article
- Article
- Effects ofBMJ open respiratory research · 2025Article
- Heterogeneity of treatment effect: the case for individualising oxygen therapy in critically ill patients.Critical care (London, England) · 2025Review
Corrections and comments
- Commented on by
Authors and funding
23 authors.
L Imeen van der WalDepartment of Intensive Care.ORCID 0000-0002-7350-0482
Chloe C A GrimDepartment of Intensive Care.ORCID 0000-0002-1662-7751
Michael R Del PradoDepartment of Intensive Care.
David J van WesterlooDepartment of Intensive Care.ORCID 0000-0002-5743-6193
E Christiaan BoermaDepartment of Sustainable Health, Campus Fryslân, University of Groningen, Groningen, The Netherlands.ORCID 0000-0001-7928-5309
Hilda G Rijnhart-de JongDepartment of Intensive Care, Medical Center Leeuwarden, Leeuwarden, The Netherlands.
Auke C ReidingaDepartment of Intensive Care, Martini Hospital, Groningen, The Netherlands.ORCID 0000-0001-6420-3649
Bert G LoefDepartment of Intensive Care, Martini Hospital, Groningen, The Netherlands.ORCID 0000-0002-6200-9591
Pim L J van der HeidenDepartment of Intensive Care, Reinier de Graaf Hospital, Delft, The Netherlands.ORCID 0000-0003-3278-4340
Marnix J SigtermansDepartment of Intensive Care, Diakonessenhuis, Utrecht, The Netherlands.
Frederique PaulusDepartment of Intensive Care and.ORCID 0000-0002-0705-1463
Alexander D CornetDepartment of Intensive Care, Medisch Spectrum Twente, Enschede, The Netherlands.ORCID 0000-0002-9917-5251
Maurizio LoconteDepartment of Anesthesiology and Intensive Care and.
F Jeannette SchoonderbeekDepartment of Intensive Care, Ikazia Hospital, Rotterdam, The Netherlands.ORCID 0000-0003-2214-0111
Nicolette F de KeizerDepartment of Medical Informatics, Amsterdam Public Health - Digital Health, Amsterdam University Medical Center, Location AMC, Amsterdam, The Netherlands.ORCID 0000-0002-6651-1730
Ferishta Bakhshi-RaiezDepartment of Medical Informatics, Amsterdam Public Health - Digital Health, Amsterdam University Medical Center, Location AMC, Amsterdam, The Netherlands.ORCID 0000-0002-5992-3032
Saskia Le CessieDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-2154-4923
Ary Serpa NetoAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.ORCID 0000-0003-1520-9387
Paolo PelosiDepartment of Anesthesiology and Intensive Care and.ORCID 0000-0001-5055-3023
Marcus J SchultzDepartment of Intensive Care and.ORCID 0000-0003-3969-7792
Hendrik J F HelmerhorstDepartment of Anesthesiology, and.ORCID 0000-0001-7921-0825
Evert de JongeDepartment of Intensive Care.ORCID 0000-0003-1431-8039
ICONIC investigators
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
COVID-19PandemicsCritical CareHumansIntensive Care UnitsOximetryRespiration, Artificialhyperoxiahypoxiaintensive care medicinemechanical ventilationoxygen
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.