Evidence map›Paper›PMID 37552378›Full record

ArticleAAPS PharmSciTech2023

Fabrication and Evaluation of Anticancer Potential of Eugenol Incorporated Chitosan-Silver Nanocomposites: In Vitro, In Vivo, and In Silico Studies.

Hamid Saeed Shah, Sumera Zaib, Muhammad Sarfraz, A Alhadhrami, Mohamed M Ibrahim, Aamir Mushtaq, Faisal Usman, Memoona Ishtiaq, Muhammad Sajjad, Hafiz Muhammad Mazhar Asjad and 1 more

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Article in AAPS PharmSciTech, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 3 countries.

Hamid Saeed ShahInstitute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, 54000, Pakistan. hamid.saeed@uvas.edu.pk.ORCID http://orcid.org/0000-0003-4396-5235
Sumera ZaibDepartment of Basic and Applied Chemistry, Faculty of Science and Technology, University of Central Punjab, Lahore, 54590, Pakistan.
Muhammad SarfrazCollege of Pharmacy, Al Ain University, Al Ain, 64141, United Arab Emirates.
A AlhadhramiDepartment of Chemistry, College of Science, Taif University, P.O. Box 11090, Taif, 21944, Saudi Arabia.
Mohamed M IbrahimDepartment of Chemistry, College of Science, Taif University, P.O. Box 11090, Taif, 21944, Saudi Arabia.
Aamir MushtaqDepartment of Pharmaceutical Sciences, Government College University, Lahore, Pakistan.
Faisal UsmanDepartment of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 66000, Pakistan.
Memoona IshtiaqLeads College of Pharmacy, Lahore LEADS University, Lahore, Pakistan.
Muhammad SajjadCollege of Pharmacy, University of Sargodha, Sargodha, Pakistan.
Hafiz Muhammad Mazhar AsjadDepartment of Pharmaceutical Sciences, Faculty of Biomedical Sciences and Engineering, Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology, Mang, Khanpur Road, Haripur-KPK, Pakistan.
Umar Farooq GoharInstitute of Industrial Biotechnology, Government College University, Lahore, Pakistan.
Government College University, Lahore · PKTaif University · SAAl Ain University · AEBahauddin Zakariya University · PKLahore Leads University · PKPak-Austria Fachhochschule: Institute of Applied Sciences and Technology · PKUniversity of Central Punjab · PKUniversity of Sargodha · PKUniversity of Veterinary and Animal Sciences · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expanding global cancer burden necessitates a comprehensive strategy to promote possible therapeutic interventions. Nanomedicine is a cutting-edge approach for treating cancer with minimal adverse effects. In the present study, chitosan-silver nanoparticles (ChAgNPs) containing Eugenol (EGN) were synthesized and evaluated for their anticancer activity against breast cancer cells (MCF-7). The physical, pharmacological, and molecular docking studies were used to characterize these nanoparticles. EGN had been effectively entrapped into hybrid NPs (84 ± 7%). The EGN-ChAgNPs had a diameter of 128 ± 14 nm, a PDI of 0.472 ± 0.118, and a zeta potential of 30.58 ± 6.92 mV. Anticancer activity was measured in vitro using an SRB assay, and the findings revealed that EGN-ChAgNPs demonstrated stronger anticancer activity against MCF-7 cells (IC

Indexed as

Antineoplastic AgentsChitosanMetal NanoparticlesNanocompositesNanoparticlesAnimalsEugenolMiceMolecular Docking SimulationSilverAntineoplastic AgentsChitosanEugenolSilvercancerchitosan-silvereugenolmolecular dockingnanoparticle

Identifiers

PMID37552378
OpenAlexW4385644581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.